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Gene Review

TPC1  -  two pore calcium channel protein 1

Arabidopsis thaliana

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High impact information on ATTPC1

  • Here, we describe the different families of (putative) cation channels: the Shakers, the two-P-domain and Kir K(+) channels (encoded by the KCO genes), the cyclic-nucleotide-gated channels, the glutamate receptors, and the Ca(2+) channel TPC1 [1].
  • Calcium channel blockers and calmodulin inhibitors added solely during the recovery phase suggest that this role for calcium is in protecting against oxidative damage specifically during/after recovery [2].
  • Thus, involvement of TPC1 channels in calcium signaling leading to development of plant defense mechanism has been suggested [3].
  • Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells [3].
  • Notably, responsiveness to H(2)O(2) was lost in the cosuppression cell line, thus TPC1 channels are required for ROS-responsive Ca(2+) influx [4].

Biological context of ATTPC1


Associations of ATTPC1 with chemical compounds

  • Sucrose-induced luminescence, which reflects a cytosolic free Ca(2+) increase in aequorin-expressing Arabidopsis leaves, was enhanced by overexpression of AtTPC1 and suppressed by antisense expression of it [6].
  • We show that a tpc1 knockout mutant lacks functional slow vacuolar channel activity and is defective in both abscisic acid-induced repression of germination and in the response of stomata to extracellular calcium [7].
  • Quantitative oxylipin analysis identified less than twofold increased jasmonate levels in healthy fou2 leaves compared to wild-type; however, wounded fou2 leaves strongly increased jasmonate biogenesis compared to wounded wild-type [8].


  1. Cation channels in the Arabidopsis plasma membrane. Véry, A.A., Sentenac, H. Trends Plant Sci. (2002) [Pubmed]
  2. Protection against heat stress-induced oxidative damage in Arabidopsis involves calcium, abscisic acid, ethylene, and salicylic acid. Larkindale, J., Knight, M.R. Plant Physiol. (2002) [Pubmed]
  3. Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells. Lin, C., Yu, Y., Kadono, T., Iwata, M., Umemura, K., Furuichi, T., Kuse, M., Isobe, M., Yamamoto, Y., Matsumoto, H., Yoshizuka, K., Kawano, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Aluminum as a specific inhibitor of plant TPC1 Ca2+ channels. Kawano, T., Kadono, T., Fumoto, K., Lapeyrie, F., Kuse, M., Isobe, M., Furuichi, T., Muto, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. Genes for calcium-permeable channels in the plasma membrane of plant root cells. White, P.J., Bowen, H.C., Demidchik, V., Nichols, C., Davies, J.M. Biochim. Biophys. Acta (2002) [Pubmed]
  6. A putative two pore channel AtTPC1 mediates Ca(2+) flux in Arabidopsis leaf cells. Furuichi, T., Cunningham, K.W., Muto, S. Plant Cell Physiol. (2001) [Pubmed]
  7. The vacuolar Ca2+-activated channel TPC1 regulates germination and stomatal movement. Peiter, E., Maathuis, F.J., Mills, L.N., Knight, H., Pelloux, J., Hetherington, A.M., Sanders, D. Nature (2005) [Pubmed]
  8. A gain-of-function allele of TPC1 activates oxylipin biogenesis after leaf wounding in Arabidopsis. Bonaventure, G., Gfeller, A., Proebsting, W.M., Hörtensteiner, S., Chételat, A., Martinoia, E., Farmer, E.E. Plant J. (2007) [Pubmed]
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