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Gene Review

CKI1  -  histidine kinase CKI1

Arabidopsis thaliana

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High impact information on CKI1

  • Functional screening of an Arabidopsis cDNA library enabled the identification of a novel cDNA, ESR1 (for Enhancer of Shoot Regeneration), that can confer cytokinin-independent shoot formation when overexpressed in Arabidopsis root explants [1].
  • We hypothesized that proteins that interact with histidine kinases throughout evolution may represent partners for Nm23-H1 and focused on the interaction of Arabidopsis "two-component" histidine kinase ERS with CTR1 [2].
  • Fourteen genes encode 22 putative histidine kinases with a conserved histidine and other typical histidine kinase signature sequences, five phosphotransfer genes encoding seven phosphotransfer proteins, and 32 response regulator genes encoding 44 proteins [3].
  • We report that a major cue for the negative regulation of sulfur acquisition is executed by cytokinin response 1 (CRE1)/wooden leg (WOL)/Arabidopsis histidine kinase 4 (AHK4) cytokinin receptor in Arabidopsis root [4].
  • We identified four histidine kinase (HK) genes of a cytokinin receptor family, two histidine-containing phosphotransmitter (HPt) genes, thirteen A-type response regulator (RR) genes and six B-type RR genes in the rice genome [5].

Biological context of CKI1


Anatomical context of CKI1

  • Each system generally consists of a sensor protein histidine kinase, which is anchored in the cell membrane, and a cytoplasmic response regulator, whose activity is modulated by the sensor [8].

Associations of CKI1 with chemical compounds

  • In this study, we characterized, in vitro, the putative cytokinin-responsive CKI1 His-kinase, in terms of His-Asp phosphorelays [9].
  • Recent information on the structure and role of six different putative ethylene receptors in tomato is discussed, including evidence supporting the receptor inhibition model for ripening, possible differences in histidine kinase activity between receptors, and the importance of receptor LeETR4 in ripening [10].

Regulatory relationships of CKI1


Other interactions of CKI1


  1. Overexpression of Arabidopsis ESR1 induces initiation of shoot regeneration. Banno, H., Ikeda, Y., Niu, Q.W., Chua, N.H. Plant Cell (2001) [Pubmed]
  2. Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. Hartsough, M.T., Morrison, D.K., Salerno, M., Palmieri, D., Ouatas, T., Mair, M., Patrick, J., Steeg, P.S. J. Biol. Chem. (2002) [Pubmed]
  3. Whole-Genome Analysis of Oryza sativa Reveals Similar Architecture of Two-Component Signaling Machinery with Arabidopsis. Pareek, A., Singh, A., Kumar, M., Kushwaha, H.R., Lynn, A.M., Singla-Pareek, S.L. Plant Physiol. (2006) [Pubmed]
  4. A novel regulatory pathway of sulfate uptake in Arabidopsis roots: implication of CRE1/WOL/AHK4-mediated cytokinin-dependent regulation. Maruyama-Nakashita, A., Nakamura, Y., Yamaya, T., Takahashi, H. Plant J. (2004) [Pubmed]
  5. Identification and characterization of cytokinin-signalling gene families in rice. Ito, Y., Kurata, N. Gene (2006) [Pubmed]
  6. Expression analysis in plant and cell suspensions of CrCKR1, a cDNA encoding a histidine kinase receptor homologue in Catharanthus roseus (L.) G. Don. Papon, N., Clastre, M., Andreu, F., Gantet, P., Rideau, M., Crèche, J. J. Exp. Bot. (2002) [Pubmed]
  7. The type-A response regulator, ARR15, acts as a negative regulator in the cytokinin-mediated signal transduction in Arabidopsis thaliana. Kiba, T., Yamada, H., Sato, S., Kato, T., Tabata, S., Yamashino, T., Mizuno, T. Plant Cell Physiol. (2003) [Pubmed]
  8. His-Asp phosphorelay signal transduction in higher plants: receptors and response regulators for cytokinin signaling in Arabidopsis thaliana. Oka, A., Sakai, H., Iwakoshi, S. Genes Genet. Syst. (2002) [Pubmed]
  9. Biochemical characterization of a putative cytokinin-responsive His-kinase, CKI1, from Arabidopsis thaliana. Nakamura, A., Kakimoto, T., Imamura, A., Suzuki, T., Ueguchi, C., Mizuno, T. Biosci. Biotechnol. Biochem. (1999) [Pubmed]
  10. Ethylene biosynthesis and action in tomato: a model for climacteric fruit ripening. Alexander, L., Grierson, D. J. Exp. Bot. (2002) [Pubmed]
  11. Novel family of sensor histidine kinase genes in Arabidopsis thaliana. Ueguchi, C., Koizumi, H., Suzuki, T., Mizuno, T. Plant Cell Physiol. (2001) [Pubmed]
  12. The AHK4 gene involved in the cytokinin-signaling pathway as a direct receptor molecule in Arabidopsis thaliana. Ueguchi, C., Sato, S., Kato, T., Tabata, S. Plant Cell Physiol. (2001) [Pubmed]
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