High impact information on ANT

• Analysis of WUS and AINTEGUMENTA functions indicates that integument initiation requires inputs from different ovule regions [1].
• The Gl15 gene encodes a putative transcription factor with significant sequence similarity to the Arabidopsis regulatory genes APETALA2 and AINTEGUMENTA, which act primarily to regulate floral organ identity and ovule development [2].
• This effect is specific to the leunig aintegumenta double mutant and is not found in other double mutant combinations such as leunig apetala2 or aintegumenta apetala2 [3].
• AINTEGUMENTA promotes petal identity and acts as a negative regulator of AGAMOUS [4].
• We propose that LEUNIG and AINTEGUMENTA act together to control the expression of common target genes that regulate cell proliferation associated with marginal tissue development [3].

Biological context of ANT

• The AINTEGUMENTA gene of Arabidopsis required for ovule and female gametophyte development is related to the floral homeotic gene APETALA2 [5].
• Plant organ size control: AINTEGUMENTA regulates growth and cell numbers during organogenesis [6].
• Pattern formation and growth during floral organogenesis: HUELLENLOS and AINTEGUMENTA are required for the formation of the proximal region of the ovule primordium in Arabidopsis thaliana [7].
• Phylogenetic analysis of the available homologous sequences strongly suggests a diphyletic origin of the eukaryotic DRG proteins [8].
• Amino acid sequences of AtDRG and PsDRG were 90% identical to each other and about 65% identical to human DRG [9].

Other interactions of ANT

• Regulation of gynoecium marginal tissue formation by LEUNIG and AINTEGUMENTA [3].
• The INNER NO OUTER (INO) and AINTEGUMENTA (ANT) genes are essential for ovule integument development in Arabidopsis thaliana [10].
• AINTEGUMENTA, an APETALA2-like gene of Arabidopsis with pleiotropic roles in ovule development and floral organ growth [11].
• In addition, we show that NOZZLE and AINTEGUMENTA, which encodes an AP2 domain transcription factor, regulate the temporal expression of INNER NO OUTER and that BELL1 is essential for INNER NO OUTER expression [12].
• Although Arabidopsis flowers develop in the apparent absence of a subtending leaf, the expression patterns of AINTEGUMENTA and SHOOT MERISTEMLESS RNAs during flower development suggest the presence of a highly reduced, "cryptic" leaf subtending the flower in Arabidopsis [13].

Analytical, diagnostic and therapeutic context of ANT

• Genomic Southern blotting indicated that AtDRG and PsDRG probably are single-copy genes [9].

References