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Gene Review:

ZAT6 - zinc finger protein ZAT6

Arabidopsis thaliana

Synonyms: C2H2, C2H2 ZINC FINGER TRANSCRIPTION FACTOR, COLD INDUCED ZINC FINGER PROTEIN 2, CZF2, T19N18.70, ...

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High impact information on C2H2

SUF4 encodes a nuclear-localized protein with two C2H2-type zinc finger motifs and a Pro-rich domain [1].
FIS2 encodes a protein with a C2H2 zinc-finger motif and three putative nuclear localization signals, indicating that it is likely to be a transcription factor [2].
KNUCKLES (KNU) encodes a C2H2 zinc-finger protein that regulates development of basal pattern elements of the Arabidopsis gynoecium [3].
The SUP gene encodes a transcription factor with a C2H2-type zinc finger motif, a serine/proline-rich domain, a basic domain, and a leucine-zipper-like domain and is expressed in a very limited region in stamen primordia and in the developing ovary during flower development [4].
The C2-H2 zinc-finger is a widely occurring DNA binding motif, usually present as tandem repeats [5].

Biological context of C2H2

A C2H2-type zinc finger protein, SGR5, is involved in early events of gravitropism in Arabidopsis inflorescence stems [6].
We also surveyed the alteration in expression of Arabidopsis transcription factor genes and established an apparent association of GRAS, bZIP, WRKY, NAC, and C2H2 transcription factor families with leaf senescence [7].
In animal systems the C2H2 zinc finger protein (ZFP) gene family is the largest group of regulatory proteins and its members have a wide and important role in growth and development [8].
C2H2 zinc-finger proteins play important roles in plant development including floral organogenesis, leaf initiation, lateral shoot initiation, gametogenesis and seed development [9].
As one possible application analysis of the zinc finger C2H2-type protein domain is introduced to illustrate the functionality of the tool [10].

Associations of C2H2 with chemical compounds

A guanine to adenine transition within a predicted C2H2 zinc finger-encoding region of MAC12.2 causes the second of two critical zinc-binding cysteine residues to be replaced by a tyrosine [3].

Other interactions of C2H2

AtZFP1, encoding Arabidopsis thaliana C2H2 zinc-finger protein 1, is expressed downstream of photomorphogenic activation [9].

References

SUPPRESSOR OF FRIGIDA4, Encoding a C2H2-Type Zinc Finger Protein, Represses Flowering by Transcriptional Activation of Arabidopsis FLOWERING LOCUS C. Kim, S., Choi, K., Park, C., Hwang, H.J., Lee, I. Plant Cell (2006) [Pubmed]
Genes controlling fertilization-independent seed development in Arabidopsis thaliana. Luo, M., Bilodeau, P., Koltunow, A., Dennis, E.S., Peacock, W.J., Chaudhury, A.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
KNUCKLES (KNU) encodes a C2H2 zinc-finger protein that regulates development of basal pattern elements of the Arabidopsis gynoecium. Payne, T., Johnson, S.D., Koltunow, A.M. Development (2004) [Pubmed]
Whorl-specific expression of the SUPERMAN gene of Arabidopsis is mediated by cis elements in the transcribed region. Ito, T., Sakai, H., Meyerowitz, E.M. Curr. Biol. (2003) [Pubmed]
Characterization of a zinc-dependent transcriptional activator from Arabidopsis. de Pater, S., Greco, V., Pham, K., Memelink, J., Kijne, J. Nucleic Acids Res. (1996) [Pubmed]
A C2H2-type zinc finger protein, SGR5, is involved in early events of gravitropism in Arabidopsis inflorescence stems. Morita, M.T., Sakaguchi, K., Kiyose, S., Taira, K., Kato, T., Nakamura, M., Tasaka, M. Plant J. (2006) [Pubmed]
Molecular events in senescing Arabidopsis leaves. Lin, J.F., Wu, S.H. Plant J. (2004) [Pubmed]
Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs. Meissner, R., Michael, A.J. Plant Mol. Biol. (1997) [Pubmed]
AtZFP1, encoding Arabidopsis thaliana C2H2 zinc-finger protein 1, is expressed downstream of photomorphogenic activation. Chrispeels, H.E., Oettinger, H., Janvier, N., Tague, B.W. Plant Mol. Biol. (2000) [Pubmed]
Species-specific analysis of protein sequence motifs using mutual information. Hummel, J., Keshvari, N., Weckwerth, W., Selbig, J. BMC Bioinformatics (2005) [Pubmed]

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