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Gene Review

PBS2  -  cysteine and histidine-rich domain...

Arabidopsis thaliana

Synonyms: ATRAR1, MIO24.17, MIO24_17, PPHB SUSCEPTIBLE 2, RAR1, ...
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High impact information on PBS2

  • RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed [1].
  • We have identified the Arabidopsis ortholog of barley RAR1 as a component of resistance specified by multiple nucleotide binding/Leu-rich repeat resistance (R) genes recognizing different bacterial and oomycete pathogen isolates [2].
  • Characterization of partially and fully defective rar1 mutations revealed that wild-type RAR1 acts as a rate-limiting regulator of early R gene-triggered defenses, determining the extent of pathogen containment, hypersensitive plant cell death, and an oxidative burst at primary infection sites [2].
  • The pbs mutations are recessive and have been mapped to chromosomes I (pbs2) and V (pbs1 and pbs3) [3].
  • Silencing of NDR1, RAR1 and HSP90, known to be required for the RPS2-mediated resistance, resulted in loss of the resistance, while silencing of EDS1 and SGT1b, which are not required for the RPS2-mediated resistance, caused no change of the resistance [4].

Biological context of PBS2

  • These data indicate that the PBS2 protein functions in a pathway that is important only to a subset of disease-resistance genes [3].
  • We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection [5].
  • These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance [6].


  1. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Tornero, P., Merritt, P., Sadanandom, A., Shirasu, K., Innes, R.W., Dangl, J.L. Plant Cell (2002) [Pubmed]
  2. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Muskett, P.R., Kahn, K., Austin, M.J., Moisan, L.J., Sadanandom, A., Shirasu, K., Jones, J.D., Parker, J.E. Plant Cell (2002) [Pubmed]
  3. Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis. Warren, R.F., Merritt, P.M., Holub, E., Innes, R.W. Genetics (1999) [Pubmed]
  4. Development of a Virus-Induced Gene-Silencing System for Functional Analysis of the RPS2-Dependent Resistance Signalling Pathways in Arabidopsis. Cai, X.Z., Xu, Q.F., Wang, C.C., Zheng, Z. Plant Mol. Biol. (2006) [Pubmed]
  5. Antagonistic control of disease resistance protein stability in the plant immune system. Holt, B.F., Belkhadir, Y., Dangl, J.L. Science (2005) [Pubmed]
  6. Regulatory role of SGT1 in early R gene-mediated plant defenses. Austin, M.J., Muskett, P., Kahn, K., Feys, B.J., Jones, J.D., Parker, J.E. Science (2002) [Pubmed]
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