The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NDR1  -  protein NDR1

Arabidopsis thaliana

Synonyms: NON-RACE SPECIFIC DISEASE RESISTANCE PROTEIN, non race-specific disease resistance 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on NDR1


Biological context of NDR1


Associations of NDR1 with chemical compounds

  • These results demonstrate that NDR1, EDS1, and PAD4 mediate other resistance signaling function(s) in addition to salicylic acid and pathogenesis-related protein accumulation [3].
  • Spermine, a novel inducer of tobacco PR (pathogenesis-related) genes, was found to up-regulate expression of NHL3, NHL10 and NDR1 [9].

Regulatory relationships of NDR1

  • Thus, RIN4 acts either cooperatively, downstream, or independently of NDR1 to negatively regulate RPS2 in the absence of pathogen [10].

Other interactions of NDR1

  • Silencing of NDR1, RAR1 and HSP90, known to be required for the RPS2-mediated resistance, resulted in loss of the resistance, while silencing of EDS1 and SGT1b, which are not required for the RPS2-mediated resistance, caused no change of the resistance [11].
  • Here, we demonstrate that unlike most CC-NBS-LRR R genes, HRT/rrt-mediated resistance is dependent on EDS1 and independent of NDR1 [12].
  • Our results suggest that RPP4-mediated resistance is developmentally regulated and that in cotyledons there is cross-talk between EDS1 and NDR1 signalling and processes regulating systemic acquired resistance [13].
  • Expression analysis of eight of these genes identified two (NHL25 and NHL3 for NDR1/HIN1-like) that show pathogen-dependent mRNA accumulation [14].
  • Green fluorescent protein-fusion experiments indicated that NHL2 and NHL10, and possibly NDR1 are localized in the chloroplasts [9].

Analytical, diagnostic and therapeutic context of NDR1

  • Sequence analysis and mass spectrometry suggest that NDR1 is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI) anchor [5].
  • GPI modification would potentially place NDR1 on the outer surface of the PM, perhaps allowing NDR1 to act as a transducer of pathogen signals and/or interact directly with the pathogen [5].


  1. NDR1, a pathogen-induced component required for Arabidopsis disease resistance. Century, K.S., Shapiro, A.D., Repetti, P.P., Dahlbeck, D., Holub, E., Staskawicz, B.J. Science (1997) [Pubmed]
  2. NDR1 Interaction with RIN4 Mediates the Differential Activation of Multiple Disease Resistance Pathways in Arabidopsis. Day, B., Dahlbeck, D., Staskawicz, B.J. Plant Cell (2006) [Pubmed]
  3. The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses. Yoshioka, K., Moeder, W., Kang, H.G., Kachroo, P., Masmoudi, K., Berkowitz, G., Klessig, D.F. Plant Cell (2006) [Pubmed]
  4. Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Lee, J., Nam, J., Park, H.C., Na, G., Miura, K., Jin, J.B., Yoo, C.Y., Baek, D., Kim, D.H., Jeong, J.C., Kim, D., Lee, S.Y., Salt, D.E., Mengiste, T., Gong, Q., Ma, S., Bohnert, H.J., Kwak, S.S., Bressan, R.A., Hasegawa, P.M., Yun, D.J. Plant J. (2007) [Pubmed]
  5. Overexpression of the plasma membrane-localized NDR1 protein results in enhanced bacterial disease resistance in Arabidopsis thaliana. Coppinger, P., Repetti, P.P., Day, B., Dahlbeck, D., Mehlert, A., Staskawicz, B.J. Plant J. (2004) [Pubmed]
  6. The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance. Mishina, T.E., Zeier, J. Plant Physiol. (2006) [Pubmed]
  7. The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathway controlled by LSD1 in Arabidopsis. Rustérucci, C., Aviv, D.H., Holt, B.F., Dangl, J.L., Parker, J.E. Plant Cell (2001) [Pubmed]
  8. The Arabidopsis NHL3 gene encodes a plasma membrane protein and its overexpression correlates with increased resistance to Pseudomonas syringae pv. tomato DC3000. Varet, A., Hause, B., Hause, G., Scheel, D., Lee, J. Plant Physiol. (2003) [Pubmed]
  9. Up-regulation of Arabidopsis thaliana NHL10 in the hypersensitive response to Cucumber mosaic virus infection and in senescing leaves is controlled by signalling pathways that differ in salicylate involvement. Zheng, M.S., Takahashi, H., Miyazaki, A., Hamamoto, H., Shah, J., Yamaguchi, I., Kusano, T. Planta (2004) [Pubmed]
  10. Arabidopsis RIN4 negatively regulates disease resistance mediated by RPS2 and RPM1 downstream or independent of the NDR1 signal modulator and is not required for the virulence functions of bacterial type III effectors AvrRpt2 or AvrRpm1. Belkhadir, Y., Nimchuk, Z., Hubert, D.A., Mackey, D., Dangl, J.L. Plant Cell (2004) [Pubmed]
  11. Development of a Virus-Induced Gene-Silencing System for Functional Analysis of the RPS2-Dependent Resistance Signalling Pathways in Arabidopsis. Cai, X.Z., Xu, Q.F., Wang, C.C., Zheng, Z. Plant Mol. Biol. (2006) [Pubmed]
  12. Signaling requirements and role of salicylic acid in HRT- and rrt-mediated resistance to turnip crinkle virus in Arabidopsis. Chandra-Shekara, A.C., Navarre, D., Kachroo, A., Kang, H.G., Klessig, D., Kachroo, P. Plant J. (2004) [Pubmed]
  13. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components. van der Biezen, E.A., Freddie, C.T., Kahn, K., Parker, J.E., Jones, J.D. Plant J. (2002) [Pubmed]
  14. NHL25 and NHL3, two NDR1/HIN1-1ike genes in Arabidopsis thaliana with potential role(s) in plant defense. Varet, A., Parker, J., Tornero, P., Nass, N., Nürnberger, T., Dangl, J.L., Scheel, D., Lee, J. Mol. Plant Microbe Interact. (2002) [Pubmed]
WikiGenes - Universities