Disease relevance of ATCNGC4

• Even in the presence of high titers of Pseudomonas syringae expressing avrRpt2, most leaf mesophyll cells in the dnd2 mutant exhibited no HR [1].

High impact information on ATCNGC4

• The HLM1 gene encodes a cyclic nucleotide-gated channel, CNGC4 [2].
• A novel mutation in Arabidopsis, hlm1, which causes aberrant regulation of cell death, manifested by a lesion-mimic phenotype and an altered HR, segregated as a single recessive allele [2].
• HLM1 gene expression is induced in response to pathogen infection and some pathogen-related signals [2].
• Preliminary study of the HLM1/CNGC4 gene pro-duct in Xenopus oocytes (inside-out patch-clamp technique) showed that CNGC4 is permeable to both K(+) and Na(+) and is activated by both cGMP and cAMP [2].
• AtERF14, a Member of the ERF Family of Transcription Factors, Plays a Nonredundant Role in Plant Defense [3].

Biological context of ATCNGC4

• Map-based cloning revealed that dnd2 phenotypes are caused by mutation of a second CNG ion channel gene, AtCNGC4 [1].
• Mutant dnd2 plants also exhibited enhanced broad-spectrum resistance against virulent P. syringae and constitutively elevated levels of salicylic acid, and pathogenesis-related (PR) gene expression [1].
• A previous mutant screen identified Arabidopsis dnd1 and dnd2 "defense, no death" mutants, which exhibit loss of hypersensitive response (HR) cell death without loss of gene-for-gene resistance [1].

Associations of ATCNGC4 with chemical compounds

• Unlike the wild type, dnd2 plants responding to virulent and avirulent P. syringae exhibited elevated expression of both salicylate-dependent PR-1 and jasmonate and ethylene-dependent PDF1 [1].
• Expression of AtCNGC2 and AtCNGC4 enhanced growth of trk1,2 in the presence of hygromycin; AtCNGC1 has less of an effect [4].

Regulatory relationships of ATCNGC4

• Ectopic Expression of the Cotton Non-symbiotic Hemoglobin Gene GhHbd1 Triggers Defense Responses and Increases Disease Tolerance in Arabidopsis [5].

Other interactions of ATCNGC4

• Arabidopsis DND2, a second cyclic nucleotide-gated ion channel gene for which mutation causes the "defense, no death" phenotype [1].

Analytical, diagnostic and therapeutic context of ATCNGC4

• Barley gene was mapped genetically to the known necrotic locus nec1 and subsequent sequence analysis identified mutations in five available nec1 alleles confirming barley homolog of Arabidopsis HLM1 as the NEC1 gene [6].

References