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Gene Review

CNGC1  -  cyclic nucleotide-gated ion channel 1

Arabidopsis thaliana

Synonyms: ATCNGC1, CYCLIC NUCLEOTIDE-GATED CHANNEL 1, MFH8.6, MFH8_6, cyclic nucleotide gated channel 1
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Disease relevance of CNGC1

  • Here, K+ uptake-deficient mutants of yeast (trk1,2) and Escherichia coli (LB650), as well as the Ca2+-uptake yeast mutant mid1,cch1, were used for functional characterization of Arabidopsis thaliana CNGCs, with the aim of identifying some of the cultural and physiological conditions that impact on plant CNGC function in heterologous systems [1].
  • Growth of trk1,2 was dependent on filter disk [K+]; suggesting that complementation of hyg hypersensitivity due to presence of a functional plant CNGC was dependent on K+ movement into the cytosol [2].

High impact information on CNGC1


Biological context of CNGC1


Other interactions of CNGC1


  1. Expression of plant cyclic nucleotide-gated cation channels in yeast. Ali, R., Zielinski, R.E., Berkowitz, G.A. J. Exp. Bot. (2006) [Pubmed]
  2. Yeast hygromycin sensitivity as a functional assay of cyclic nucleotide gated cation channels. Mercier, R.W., Rabinowitz, N.M., Ali, R., Gaxiola, R.A., Berkowitz, G.A. Plant Physiol. Biochem. (2004) [Pubmed]
  3. HLM1, an essential signaling component in the hypersensitive response, is a member of the cyclic nucleotide-gated channel ion channel family. Balagué, C., Lin, B., Alcon, C., Flottes, G., Malmström, S., Köhler, C., Neuhaus, G., Pelletier, G., Gaymard, F., Roby, D. Plant Cell (2003) [Pubmed]
  4. The Arabidopsis dnd1 "defense, no death" gene encodes a mutated cyclic nucleotide-gated ion channel. Clough, S.J., Fengler, K.A., Yu, I.C., Lippok, B., Smith, R.K., Bent, A.F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Ozone-induced programmed cell death in the Arabidopsis radical-induced cell death1 mutant. Overmyer, K., Brosché, M., Pellinen, R., Kuittinen, T., Tuominen, H., Ahlfors, R., Keinänen, M., Saarma, M., Scheel, D., Kangasjärvi, J. Plant Physiol. (2005) [Pubmed]
  6. Electrophysiological analysis of cloned cyclic nucleotide-gated ion channels. Leng, Q., Mercier, R.W., Hua, B.G., Fromm, H., Berkowitz, G.A. Plant Physiol. (2002) [Pubmed]
  7. Expression of a truncated tobacco NtCBP4 channel in transgenic plants and disruption of the homologous Arabidopsis CNGC1 gene confer Pb2+ tolerance. Sunkar, R., Kaplan, B., Bouché, N., Arazi, T., Dolev, D., Talke, I.N., Maathuis, F.J., Sanders, D., Bouchez, D., Fromm, H. Plant J. (2000) [Pubmed]
  8. Arabidopsis thaliana cyclic nucleotide gated channel 3 forms a non-selective ion transporter involved in germination and cation transport. Gobert, A., Park, G., Amtmann, A., Sanders, D., Maathuis, F.J. J. Exp. Bot. (2006) [Pubmed]
  9. Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana. Köhler, C., Neuhaus, G. FEBS Lett. (2000) [Pubmed]
  10. Arabidopsis DND2, a second cyclic nucleotide-gated ion channel gene for which mutation causes the "defense, no death" phenotype. Jurkowski, G.I., Smith, R.K., Yu, I.C., Ham, J.H., Sharma, S.B., Klessig, D.F., Fengler, K.A., Bent, A.F. Mol. Plant Microbe Interact. (2004) [Pubmed]
  11. Developmentally regulated expression of a cyclic nucleotide-gated ion channel from Arabidopsis indicates its involvement in programmed cell death. Köhler, C., Merkle, T., Roby, D., Neuhaus, G. Planta (2001) [Pubmed]
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