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PRF3  -  profilin 3

Arabidopsis thaliana

Synonyms: MIK19.4, MIK19_4, PFN3, PROFILIN, PROFILIN 3
 
 
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High impact information on PFN3/PRF3

  • The ability of profilin to regulate actin polymerization and participate directly in signal transduction pathways is discussed in light of the prf1-1 phenotypes [1].
  • Analysis of the Arabidopsis genome sequence indicates that, unlike animals and fungi, formins are the only class of conserved profilin-binding PLP proteins in plants [2].
  • How profilin uses the ATP hydrolysis that accompanies actin polymerization and whether the acceleration of nucleotide exchange on G-actin by profilin participates in its function in filament assembly are the issues addressed here [3].
  • Root hair formation: F-actin-dependent tip growth is initiated by local assembly of profilin-supported F-actin meshworks accumulated within expansin-enriched bulges [4].
  • Profilin (PFN) is an ubiquitous, low-M(r), actin-binding protein involved in the organization of the cytoskeleton of eukaryotes including higher plants [5].
 

Biological context of PFN3/PRF3

  • Role of nucleotide exchange and hydrolysis in the function of profilin in action assembly [3].
  • Gene trees constructed from amino acid sequence data revealed the presence of two ancient, distinct profilin gene classes in plants [6].
  • Profilin plays a role in cell elongation, cell shape maintenance, and flowering in Arabidopsis [5].
 

Anatomical context of PFN3/PRF3

  • Profilin is a ubiquitous eukaryotic protein that regulates the actin cytoskeleton and recently has been identified as a potent allergen in pollen [6].
  • All but one of the murine B cell epitopes defined in this work were located on the surface of the profilin molecule in the alpha-helices (10A4 and 3H8) or in the turns (5F2 and 9G4) [7].
 

Analytical, diagnostic and therapeutic context of PFN3/PRF3

  • Immunoblotting of lines expressing a profilin PRF1 3' untranslated region (UTR)-specific construct demonstrated a 77 to 97% reduction in PRF1 protein, but not other profilin isovariants [8].
  • The presence of marker molecules such as profilin, the low occurrence of chloroplast-related mRNAs, and the sieve element localization of constituent mRNA using in situ hybridization were consistent with a phloem origin of the sap [9].

References

  1. Small changes in the regulation of one Arabidopsis profilin isovariant, PRF1, alter seedling development. McKinney, E.C., Kandasamy, M.K., Meagher, R.B. Plant Cell (2001) [Pubmed]
  2. Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Deeks, M.J., Hussey, P.J., Davies, B. Trends Plant Sci. (2002) [Pubmed]
  3. Role of nucleotide exchange and hydrolysis in the function of profilin in action assembly. Perelroizen, I., Didry, D., Christensen, H., Chua, N.H., Carlier, M.F. J. Biol. Chem. (1996) [Pubmed]
  4. Root hair formation: F-actin-dependent tip growth is initiated by local assembly of profilin-supported F-actin meshworks accumulated within expansin-enriched bulges. Baluska, F., Salaj, J., Mathur, J., Braun, M., Jasper, F., Samaj, J., Chua, N.H., Barlow, P.W., Volkmann, D. Dev. Biol. (2000) [Pubmed]
  5. Profilin plays a role in cell elongation, cell shape maintenance, and flowering in Arabidopsis. Ramachandran, S., Christensen, H.E., Ishimaru, Y., Dong, C.H., Chao-Ming, W., Cleary, A.L., Chua, N.H. Plant Physiol. (2000) [Pubmed]
  6. The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes. Huang, S., McDowell, J.M., Weise, M.J., Meagher, R.B. Plant Physiol. (1996) [Pubmed]
  7. Molecular and structural analysis of the panallergen profilin B cell epitopes defined by monoclonal antibodies. Asturias, J.A., Gómez-Bayón, N., Arilla, M.C., Sánchez-Pulido, L., Valencia, A., Martínez, A. Int. Immunol. (2002) [Pubmed]
  8. Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference. Pawloski, L.C., Deal, R.B., McKinney, E.C., Burgos-Rivera, B., Meagher, R.B. Plant Cell Physiol. (2005) [Pubmed]
  9. A phloem-enriched cDNA library from Ricinus: insights into phloem function. Doering-Saad, C., Newbury, H., Couldridge, C., Bale, J., Pritchard, J. J. Exp. Bot. (2006) [Pubmed]
 
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