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Gene Review

PRF1  -  profilin 1

Arabidopsis thaliana

Synonyms: F6F22.21, F6F22_21, PFN1, PROFILIN 1
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Disease relevance of PFN1/PRF1

  • Plant profilins are of interest because immunological cross-reactivity between pollen and human profilin may be the cause of hay fever and broad allergies to pollens [1].

High impact information on PFN1/PRF1


Biological context of PFN1/PRF1


Anatomical context of PFN1/PRF1

  • Taken together, these data suggest that the group Ie formins act with profilin to regulate actin polymerization at specific sites associated with the cell membrane [5].

Other interactions of PFN1/PRF1


Analytical, diagnostic and therapeutic context of PFN1/PRF1


  1. The crystal structure of a major allergen from plants. Thorn, K.S., Christensen, H.E., Shigeta, R., Huddler, D., Shalaby, L., Lindberg, U., Chua, N.H., Schutt, C.E. Structure (1997) [Pubmed]
  2. Small changes in the regulation of one Arabidopsis profilin isovariant, PRF1, alter seedling development. McKinney, E.C., Kandasamy, M.K., Meagher, R.B. Plant Cell (2001) [Pubmed]
  3. Distinct roles of the first introns on the expression of Arabidopsis profilin gene family members. Jeong, Y.M., Mun, J.H., Lee, I., Woo, J.C., Hong, C.B., Kim, S.G. Plant Physiol. (2006) [Pubmed]
  4. Molecular cloning and mRNA localization of tomato pollen profilin. Yu, L.X., Nasrallah, J., Valenta, R., Parthasarathy, M.V. Plant Mol. Biol. (1998) [Pubmed]
  5. Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. Deeks, M.J., Cvrcková, F., Machesky, L.M., Mikitová, V., Ketelaar, T., Zársky, V., Davies, B., Hussey, P.J. New Phytol. (2005) [Pubmed]
  6. The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes. Huang, S., McDowell, J.M., Weise, M.J., Meagher, R.B. Plant Physiol. (1996) [Pubmed]
  7. A phloem-enriched cDNA library from Ricinus: insights into phloem function. Doering-Saad, C., Newbury, H., Couldridge, C., Bale, J., Pritchard, J. J. Exp. Bot. (2006) [Pubmed]
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