Disease relevance of ATAF1

• ATAF1 mRNA expression was strongly induced by dehydration and abscisic acid (ABA) treatment, but inhibited by water treatment, suggesting a general role in drought stress responses [1].

High impact information on ATAF1

• Here, we demonstrate that the Arabidopsis thaliana NAC (for NAM, ATAF1/2, and CUC2) domain transcription factor, SND1 (for secondary wall-associated NAC domain protein), is a key transcriptional switch regulating secondary wall synthesis in fibers [2].
• A novel drought-inducible gene, ATAF1, encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis [1].
• Furthermore, domain deletion analysis revealed that the ATAF1 transactivation activity was conferred by its C-terminal domain [1].
• Yeast transactivation analysis showed that ATAF1 had ability to activate reporter gene expression [1].
• Five BnNAC proteins were orthologous to Arabidopsis thaliana ATAF1 or ATAF2 and gave rise to developmental abnormalities similar to the A. thaliana nam and cuc mutants when expressed ectopically in A. thaliana [3].
• Acquistion of pluripotentiality results in changes in methylation patterns and induction of ATAF1 and 3 other NAC genes [4].

Biological context of ATAF1

• We observed a reduction in DNA methylation at a pericentromeric region of chromosome 1, and up-regulation of several members of the NAC (NAM/ATAF1/CUC2) domain family, two of which are located near the telomeric region of chromosome 1 [5].

Other interactions of ATAF1

• Arabidopsis ATAF1 and ATAF2 were also shown to be induced by wounding [6].
• Induced by Blumeria graminis [7]

References