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AXR3  -  auxin-responsive protein IAA17

Arabidopsis thaliana

Synonyms: AUXIN RESISTANT 3, F19P19.31, F19P19_31, IAA17, indole-3-acetic acid inducible 17
 
 
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High impact information on AXR3

  • We demonstrate that SCF(TIR1) interacts with AXR2/IAA7 and AXR3/IAA17, and that domain II of these proteins is necessary and sufficient for this interaction [1].
  • Changes in diverse auxin responses result from mutations in the Arabidopsis AXR3 gene [2].
  • Furthermore, hobbit mutants show a reduction in DR5 :: GUS auxin reporter gene expression and accumulate the AXR3/IAA17 repressor of auxin responses [3].
  • Selectively disrupting the auxin responsiveness of expanding epidermal cells by expressing a mutant form of the AUX/IAA17 protein, axr3-1, abolished root gravitropism [4].
  • Both sar1 and sar3 mutations affect the localization of the transcriptional repressor AXR3/INDOLE ACETIC ACID17, providing a likely explanation for suppression of the phenotype conferred by axr1 [5].
 

Biological context of AXR3

  • IAA17/AXR3: biochemical insight into an auxin mutant phenotype [6].
  • Mutant axr3 plants show enhanced apical dominance, reduced root elongation, increased adventitious rooting, no root gravitropism, and ectopic expression from the SAUR-AC1 promoter [7].
  • Single amino acid substitutions of PSIAA6 in conserved domain II, equivalent to those found in two alleles of axr3, a gene that encodes Aux/IAA protein IAA17, resulted in a greater than 50-fold increase in protein accumulation [8].
 

Other interactions of AXR3

  • AXR3 and SHY2 interact to regulate root hair development [9].
  • Auxin regulates turnover of the related Auxin-resistant (AXR)2/IAA7 and AXR3/IAA17 proteins by increasing their interaction with the Skp1-Cdc53/cullin-F-box (SCFTIR1) E3 ubiquitin ligase complex [10].

References

  1. Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins. Gray, W.M., Kepinski, S., Rouse, D., Leyser, O., Estelle, M. Nature (2001) [Pubmed]
  2. Changes in auxin response from mutations in an AUX/IAA gene. Rouse, D., Mackay, P., Stirnberg, P., Estelle, M., Leyser, O. Science (1998) [Pubmed]
  3. The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation. Blilou, I., Frugier, F., Folmer, S., Serralbo, O., Willemsen, V., Wolkenfelt, H., Eloy, N.B., Ferreira, P.C., Weisbeek, P., Scheres, B. Genes Dev. (2002) [Pubmed]
  4. Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal. Swarup, R., Kramer, E.M., Perry, P., Knox, K., Leyser, H.M., Haseloff, J., Beemster, G.T., Bhalerao, R., Bennett, M.J. Nat. Cell Biol. (2005) [Pubmed]
  5. The Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE proteins are nucleoporins with an important role in hormone signaling and development. Parry, G., Ward, S., Cernac, A., Dharmasiri, S., Estelle, M. Plant Cell (2006) [Pubmed]
  6. IAA17/AXR3: biochemical insight into an auxin mutant phenotype. Ouellet, F., Overvoorde, P.J., Theologis, A. Plant Cell (2001) [Pubmed]
  7. Mutations in the AXR3 gene of Arabidopsis result in altered auxin response including ectopic expression from the SAUR-AC1 promoter. Leyser, H.M., Pickett, F.B., Dharmasiri, S., Estelle, M. Plant J. (1996) [Pubmed]
  8. Degradation of Aux/IAA proteins is essential for normal auxin signalling. Worley, C.K., Zenser, N., Ramos, J., Rouse, D., Leyser, O., Theologis, A., Callis, J. Plant J. (2000) [Pubmed]
  9. AXR3 and SHY2 interact to regulate root hair development. Knox, K., Grierson, C.S., Leyser, O. Development (2003) [Pubmed]
  10. Regulation of Arabidopsis SHY2/IAA3 protein turnover. Tian, Q., Nagpal, P., Reed, J.W. Plant J. (2003) [Pubmed]
 
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