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Gene Review

SHY2  -  auxin-responsive protein IAA3

Arabidopsis thaliana

Synonyms: F19P19.32, F19P19_32, IAA3, SHORT HYPOCOTYL 2, indole-3-acetic acid inducible 3
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Disease relevance of SHY2


High impact information on SHY2


Biological context of SHY2

  • The phenotypes suggest that SHY2/IAA3 may activate some auxin responses and repress others [7].
  • Metabolic labeling and immunoprecipitation studies with affinity-purified antibodies to IAA3 demonstrate increased in vivo steady-state levels of mutant IAA3 in shy2-2 plants and phosphorylation of the SHY2-2 protein in vivo [8].
  • Gain-of-function and loss-of-function shy2 mutations affect auxin-dependent root growth, lateral root formation, and timing of gravitropism, indicating that SHY2/IAA3 regulates multiple auxin responses in roots [7].
  • The short hypocotyl of seedlings underexpressing CDC2b was a result of inhibition of cell elongation rather than a reduction in cell number, whereas in cotyledons, inhibition of CDC2b expression resulted in large, open cotyledons with amyloplasts rather than etioplasts [9].

Associations of SHY2 with chemical compounds


Regulatory relationships of SHY2


Other interactions of SHY2


Analytical, diagnostic and therapeutic context of SHY2

  • Recent molecular cloning revealed that the SHY2 gene is identical to the IAA3 gene, a member of the primary auxin-response genes designated the Aux/IAA gene family [17].


  1. Expression of an Arabidopsis cryptochrome gene in transgenic tobacco results in hypersensitivity to blue, UV-A, and green light. Lin, C., Ahmad, M., Gordon, D., Cashmore, A.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. Weijers, D., Benkova, E., Jäger, K.E., Schlereth, A., Hamann, T., Kientz, M., Wilmoth, J.C., Reed, J.W., Jürgens, G. EMBO J. (2005) [Pubmed]
  3. HYPERSENSITIVE TO RED AND BLUE 1, a ZZ-type zinc finger protein, regulates phytochrome B-mediated red and cryptochrome-mediated blue light responses. Kang, X., Chong, J., Ni, M. Plant Cell (2005) [Pubmed]
  4. Reserve mobilization in the Arabidopsis endosperm fuels hypocotyl elongation in the dark, is independent of abscisic acid, and requires PHOSPHOENOLPYRUVATE CARBOXYKINASE1. Penfield, S., Rylott, E.L., Gilday, A.D., Graham, S., Larson, T.R., Graham, I.A. Plant Cell (2004) [Pubmed]
  5. IBR5, a dual-specificity phosphatase-like protein modulating auxin and abscisic acid responsiveness in Arabidopsis. Monroe-Augustus, M., Zolman, B.K., Bartel, B. Plant Cell (2003) [Pubmed]
  6. Arabidopsis SHY2/IAA3 inhibits auxin-regulated gene expression. Tian, Q., Uhlir, N.J., Reed, J.W. Plant Cell (2002) [Pubmed]
  7. Control of auxin-regulated root development by the Arabidopsis thaliana SHY2/IAA3 gene. Tian, Q., Reed, J.W. Development (1999) [Pubmed]
  8. Aux/IAA proteins are phosphorylated by phytochrome in vitro. Colón-Carmona, A., Chen, D.L., Yeh, K.C., Abel, S. Plant Physiol. (2000) [Pubmed]
  9. An Arabidopsis cell cycle -dependent kinase-related gene, CDC2b, plays a role in regulating seedling growth in darkness. Yoshizumi, T., Nagata, N., Shimada, H., Matsui, M. Plant Cell (1999) [Pubmed]
  10. Regulation of Arabidopsis SHY2/IAA3 protein turnover. Tian, Q., Nagpal, P., Reed, J.W. Plant J. (2003) [Pubmed]
  11. A turanose-insensitive mutant suggests a role for WOX5 in auxin homeostasis in Arabidopsis thaliana. Gonzali, S., Novi, G., Loreti, E., Paolicchi, F., Poggi, A., Alpi, A., Perata, P. Plant J. (2005) [Pubmed]
  12. Dominant negative suppression of arabidopsis photoresponses by mutant phytochrome A sequences identifies spatially discrete regulatory domains in the photoreceptor. Boylan, M., Douglas, N., Quail, P.H. Plant Cell (1994) [Pubmed]
  13. AXR3 and SHY2 interact to regulate root hair development. Knox, K., Grierson, C.S., Leyser, O. Development (2003) [Pubmed]
  14. Two dominant photomorphogenic mutations of Arabidopsis thaliana identified as suppressor mutations of hy2. Kim, B.C., Soh, M.C., Kang, B.J., Furuya, M., Nam, H.G. Plant J. (1996) [Pubmed]
  15. DFL2, a new member of the Arabidopsis GH3 gene family, is involved in red light-specific hypocotyl elongation. Takase, T., Nakazawa, M., Ishikawa, A., Manabe, K., Matsui, M. Plant Cell Physiol. (2003) [Pubmed]
  16. COP1b, an isoform of COP1 generated by alternative splicing, has a negative effect on COP1 function in regulating light-dependent seedling development in Arabidopsis. Zhou, D.X., Kim, Y.J., Li, Y.F., Carol, P., Mache, R. Mol. Gen. Genet. (1998) [Pubmed]
  17. Expression pattern of Aux/IAA genes in the iaa3/shy2-1D mutant of Arabidopsis thaliana (L.). Oono, Y., Ooura, C., Uchimiya, H. Ann. Bot. (2002) [Pubmed]
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