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Gene Review

RAB6C  -  RAB6C, member RAS oncogene family

Homo sapiens

Synonyms: Rab6-like protein WTH3, Ras-related protein Rab-6C, WTH3
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Disease relevance of RAB6C


High impact information on RAB6C

  • A reverse correlation between WTH3 and MDR1 gene expression was also observed in MCF7/AdrR, and its non-MDR parental cell line, MCF7/WT [1].
  • Interestingly, we found that a CpG (CpG 23) that was close to the TATA-like box was constantly methylated in the WTH3 promoter of drug-resistant breast cancer epithelial and cultured MDR cells [1].
  • This hypothesis was supported by data obtained from introducing the WTH3 transgene into MDR cell lines, which reduced endogenous MDR1 expression [1].
  • This result indicated that both DNA methylation and histone deacetylase could act in concert to inhibit WTH3 and consequently stimulate MDR1 expression [1].
  • Therefore, our studies suggested that the behavior of WTH3 in primary drug-resistant breast cancer epithelial cells was similar to that in a model system where epigenetic regulation of the WTH3 gene was linked to the MDR phenotype [1].

Biological context of RAB6C


Anatomical context of RAB6C

  • Results showed that WTH3 was mainly located in the cytosol and capable of binding to GTP [3].

Associations of RAB6C with chemical compounds

  • We also discovered that MCF7/AdrR cells treated with trichostatin A, a histone deacetylase inhibitor, exhibited higher WTH3, but lower MDR1, expression [1].
  • Permanent expression of the WTH3 transgene in MDR cell lines increased to varying degrees their sensitivity to several anticancer drugs, which included doxorubicin, taxol, vinblastine, vincristine, and etoposide, as compared to the control sublines transfected with the empty vector [2].

Other interactions of RAB6C


Analytical, diagnostic and therapeutic context of RAB6C


  1. Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. Tian, K., Jurukovski, V., Wang, X.P., Kaplan, M.H., Xu, H. Cancer Res. (2005) [Pubmed]
  2. WTH3, a new member of the Rab6 gene family, and multidrug resistance. Shan, J., Yuan, L., Budman, D.R., Xu, H.P. Biochim. Biophys. Acta (2002) [Pubmed]
  3. WTH3, which encodes a small G protein, is differentially regulated in multidrug-resistant and sensitive MCF7 cells. Tian, K., Jurukovski, V., Yuan, L., Shan, J., Xu, H. Cancer Res. (2005) [Pubmed]
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