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Gene Review

FKF1  -  flavin-binding, kelch repeat, f box 1

Arabidopsis thaliana

Synonyms: "flavin-binding, kelch repeat, f box 1", ADO3, T23K23.10, T23K23_10, f box 1, ...
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High impact information on FKF1

  • FKF1 mRNA levels oscillate with a circadian rhythm, and deletion of FKF1 alters the waveform of rhythmic expression of two clock-controlled genes, implicating FKF1 in modulating the Arabidopsis circadian clock [1].
  • We positionally cloned FKF1, which encodes a novel protein with a PAS domain similar to the flavin-binding region of certain photoreceptors, an F box characteristic of proteins that direct ubiquitin-mediated degradation, and six kelch repeats predicted to fold into a beta propeller [1].
  • Studies of the plant phototropins have identified 11 flavin-contacting residues that are also conserved in the LOV domains of WC-1, VVD, and FKF1 [2].
  • Furthermore, we show that the Neurosporastrains containing a chimeric WC-1 protein with the LOV domain from FKF1 or phot1 can also sense light, suggesting that FKF1 and its related proteins are light sensors in Arabidopsis [2].
  • Flavin-binding, Kelch repeat, F-box (FKF1) protein is a photoreceptor to regulate flowering of Arabidopsis [3].

Regulatory relationships of FKF1

  • Thus, FKF1 controls daily CO expression in part by degrading CDF1, a repressor of CO transcription [4].

Other interactions of FKF1


Analytical, diagnostic and therapeutic context of FKF1

  • In the present study, a LOV-containing polypeptide of FKF1 was prepared by an overexpression system, and the quaternary structure of it was studied by size exclusion chromatography and small-angle X-ray scattering [3].


  1. FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Nelson, D.C., Lasswell, J., Rogg, L.E., Cohen, M.A., Bartel, B. Cell (2000) [Pubmed]
  2. Functional conservation of light, oxygen, or voltage domains in light sensing. Cheng, P., He, Q., Yang, Y., Wang, L., Liu, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Quaternary structure of LOV-domain containing polypeptide of Arabidopsis FKF1 protein. Nakasako, M., Matsuoka, D., Zikihara, K., Tokutomi, S. FEBS Lett. (2005) [Pubmed]
  4. FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Imaizumi, T., Schultz, T.F., Harmon, F.G., Ho, L.A., Kay, S.A. Science (2005) [Pubmed]
  5. Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis. Yasuhara, M., Mitsui, S., Hirano, H., Takanabe, R., Tokioka, Y., Ihara, N., Komatsu, A., Seki, M., Shinozaki, K., Kiyosue, T. J. Exp. Bot. (2004) [Pubmed]
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