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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ackr3  -  atypical chemokine receptor 3

Rattus norvegicus

Synonyms: Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CXC-R7, CXCR-7, Chemokine orphan receptor 1, ...
 
 
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Disease relevance of Cmkor1

 

High impact information on Cmkor1

  • Messenger RNA species coding for three putative ADM receptors (the L1 orphan receptor, RDC-1, and calcitonin receptor-like receptor) and accessory proteins (receptor-activity modifying proteins) were present in astrocytes [1].
  • CGRP, RAMP1, and RDC-1 ASODNs significantly elevated pulmonary artery pressure (PPA) in chronic hypoxic rats compared with hypoxic mismatched ASODN (MMODN) and saline vehicle controls [2].
  • Our results show upregulation of RDC-1, RAMP1, and RAMP3 mRNAs in hypoxic rat lung and no change in CRLR and RAMP2 mRNAs [3].
  • The high level of expression of RDC1 and CRLR suggests that both AM and CGRP may have direct actions on the cardiac myocyte via common receptors that can interact with either ligand [4].
  • We have recently reported the cloning and expression of an adrenomedullin receptor which is approximately 30% homologous to the canine orphan receptor RDC-1 [5].
 

Biological context of Cmkor1

 

Anatomical context of Cmkor1

  • In the present study, we used real-time quantitative RT-PCR to detect and quantitate the relative expression of CGRP, CRLR, RAMP1-3 and RDC-1 in the nucleus accumbens of intact rats and rats with inflammation [6].

References

  1. Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier. Ladoux, A., Frelin, C. J. Biol. Chem. (2000) [Pubmed]
  2. Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats. Qing, X., Keith, I.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  3. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing, X., Svaren, J., Keith, I.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  4. Cardiac expression of genes encoding putative adrenomedullin/calcitonin gene-related peptide receptors. Autelitano, D.J. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor. Kapas, S., Clark, A.J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  6. Expression of calcitonin gene-related peptide type 1 receptor mRNA and their activity-modifying proteins in the rat nucleus accumbens. Li, N., Fang, C.Y., Wang, Z.Z., Wang, Y.L., Wang, F.B., Gao, E., Zhang, G.X. Neurosci. Lett. (2004) [Pubmed]
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