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Gene Review

ACKR3  -  atypical chemokine receptor 3

Homo sapiens

Synonyms: Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CMKOR1, CXC-R7, CXCR-7, ...
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Disease relevance of CXCR7


High impact information on CXCR7

  • RDC1 may not be VIP receptor [7].
  • We indeed report that CpG-activated plasmacytoid DC produce a putative ligand for RDC1, which selectively down-regulates RDC1, but not CXCR4 on primary human B cells [8].
  • Based on phylogenetic analysis and chromosomal mapping, the orphan receptor RDC1 was proposed to be a chemokine receptor [8].
  • In blood-derived switch memory B cells, the expression of RDC1 appeared to correlate with the ability to differentiate into plasma cells upon activation, suggesting that RDC1 is a marker for memory B cells, which are competent to become Ab-secreting cells [8].
  • In this study we examined the expression of RDC1 on leukocytes by measuring mRNA levels and receptor expression using a new specific mAb [8].

Biological context of CXCR7


Anatomical context of CXCR7

  • The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes [1].
  • RDC1 expression was found to be tightly regulated during B cell development and differentiation [8].
  • When a CD4-expressing cell line, NP-2/CD4, which shows strict resistance to infection not only with HIV-1 but also with HIV-2 or SIV, was transduced with the RDC1 gene, the cells became highly susceptible to HIV-2 and SIV(mnd) strains but to neither M- nor T-tropic HIV-1 strains [2].
  • Treatment of human primary chondrocytes with RDC1 agonist induced a Ca2+ response, suggesting the receptor is active in this tissue type [4].

Other interactions of CXCR7

  • Furthermore, we provide evidence that interaction of CXCL12 with RDC1 is specific, saturable, and of high affinity (apparent KD approximately 0.4 nM) [1].
  • The results indicate that human RDC1, RDC4, RDC7, and RDC8 are in regions 2q37, 1p34.3-1p36.3, 22q11.2-22q13.1, and 11q11-11q13, respectively [10].
  • Characterization of the G-protein linked orphan receptor GPRN1/RDC1 [11].

Analytical, diagnostic and therapeutic context of CXCR7


  1. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. Balabanian, K., Lagane, B., Infantino, S., Chow, K.Y., Harriague, J., Moepps, B., Arenzana-Seisdedos, F., Thelen, M., Bachelerie, F. J. Biol. Chem. (2005) [Pubmed]
  2. A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. Shimizu, N., Soda, Y., Kanbe, K., Liu, H.Y., Mukai, R., Kitamura, T., Hoshino, H. J. Virol. (2000) [Pubmed]
  3. Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. Broberg, K., Zhang, M., Strömbeck, B., Isaksson, M., Nilsson, M., Mertens, F., Mandahl, N., Panagopoulos, I. Int. J. Oncol. (2002) [Pubmed]
  4. The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Jones, S.W., Brockbank, S.M., Mobbs, M.L., Le Good, N.J., Soma-Haddrick, S., Heuze, A.J., Langham, C.J., Timms, D., Newham, P., Needham, M.R. Osteoarthr. Cartil. (2006) [Pubmed]
  5. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Miao, Z., Luker, K.E., Summers, B.C., Berahovich, R., Bhojani, M.S., Rehemtulla, A., Kleer, C.G., Essner, J.J., Nasevicius, A., Luker, G.D., Howard, M.C., Schall, T.J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. Wang, J., Shiozawa, Y., Wang, J., Wang, Y., Jung, Y., Pienta, K.J., Mehra, R., Loberg, R., Taichman, R.S. J. Biol. Chem. (2008) [Pubmed]
  7. RDC1 may not be VIP receptor. Nagata, S., Ishihara, T., Robberecht, P., Libert, F., Parmentier, M., Christophe, J., Vassart, G. Trends Pharmacol. Sci. (1992) [Pubmed]
  8. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. Infantino, S., Moepps, B., Thelen, M. J. Immunol. (2006) [Pubmed]
  9. Hematopoietic Progenitor Cells (HPC) from Mobilized Peripheral Blood Display Enhanced Migration and Marrow Homing Compared to Steady-State Bone Marrow HPC. Bonig, H., Priestley, G.V., Oehler, V., Papayannopoulou, T. Exp. Hematol. (2007) [Pubmed]
  10. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Libert, F., Passage, E., Parmentier, M., Simons, M.J., Vassart, G., Mattei, M.G. Genomics (1991) [Pubmed]
  11. Characterization of the G-protein linked orphan receptor GPRN1/RDC1. Law, N.M., Rosenzweig, S.A. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
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