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Gene Review

MEU1  -  S-methyl-5-thioadenosine phosphorylase

Saccharomyces cerevisiae S288c

Synonyms: 5'-methylthioadenosine phosphorylase, L1595, MTA phosphorylase, MTAP, MTAPase, ...
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High impact information on MEU1


Biological context of MEU1


Associations of MEU1 with chemical compounds

  • In both MEU1(+) and the meu1Delta cultures, the ODC levels were markedly decreased by the addition of spermidine to the media, and thus our results contradict the postulation of Subhi et al [1].
  • The meu1Delta cells have a higher putrescine and a lower spermidine level than MEU1(+) cells, suggesting that the decreased spermidine level in the meu1Delta cultures is responsible for the greater apparent stability of ODC in the meu1Delta cells [1].
  • In contrast, in MEU1+ SPE2+ cells methylthioadenosine does not accumulate and is metabolized through the methionine salvage pathway [3].


  1. Studies on the regulation of ornithine decarboxylase in yeast: effect of deletion in the MEU1 gene. Chattopadhyay, M.K., Tabor, C.W., Tabor, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Isolation and identification of genes activating UAS2-dependent ADH2 expression in Saccharomyces cerevisiae. Donoviel, M.S., Young, E.T. Genetics (1996) [Pubmed]
  3. Methylthioadenosine and polyamine biosynthesis in a Saccharomyces cerevisiae meu1delta mutant. Chattopadhyay, M.K., Tabor, C.W., Tabor, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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