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Gene Review

Mtap  -  methylthioadenosine phosphorylase

Mus musculus

Synonyms: 1300019I21Rik, 5'-methylthioadenosine phosphorylase, MSAP, MTA phosphorylase, MTAP, ...
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Disease relevance of Mtap


High impact information on Mtap


Chemical compound and disease context of Mtap

  • Here we show that MRLC-interacting protein (MIR)-interacting saposin-like protein (MSAP) enhances cell spreading in fibroblasts and migration of rat C6 glioma cells through increases in MRLC phosphorylation [4].

Biological context of Mtap


Anatomical context of Mtap


Associations of Mtap with chemical compounds


  1. Molecular characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase-deficient mutant clones of murine lymphoma cell line R1.1. Kadariya, Y., Nishioka, J., Nakamura, A., Kato-Nakazawa, K., Nobori, T. Cancer Sci. (2003) [Pubmed]
  2. Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts. Kubota, M., Kajander, E.O., Carson, D.A. Cancer Res. (1985) [Pubmed]
  3. Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines. Pera, P.J., Kramer, D.L., Sufrin, J.R., Porter, C.W. Cancer Res. (1986) [Pubmed]
  4. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. Bornhauser, B.C., Lindholm, D. Cell. Mol. Life Sci. (2005) [Pubmed]
  5. In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides. Bacchi, C.J., Sanabria, K., Spiess, A.J., Vargas, M., Marasco, C.J., Jimenez, L.M., Goldberg, B., Sufrin, J.R. Antimicrob. Agents Chemother. (1997) [Pubmed]
  6. Altered gene expression in liver from a murine model of hyperhomocysteinemia. Robert, K., Chassé, J.F., Santiard-Baron, D., Vayssettes, C., Chabli, A., Aupetit, J., Maeda, N., Kamoun, P., London, J., Janel, N. J. Biol. Chem. (2003) [Pubmed]
  7. 5-Methylthioribose. Its effects and function in mammalian cells. Riscoe, M.K., Ferro, A.J. J. Biol. Chem. (1984) [Pubmed]
  8. Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line. Kubota, M., Kamatani, N., Carson, D.A. J. Biol. Chem. (1983) [Pubmed]
  9. Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine. Sufrin, J.R., Spiess, A.J., Kramer, D.L., Libby, P.R., Miller, J.T., Bernacki, R.J., Lee, Y.H., Borchardt, R.T., Porter, C.W. J. Med. Chem. (1991) [Pubmed]
  10. MSAP, the meichroacidin homolog of carp (Cyprinus carpio), differs from the rodent counterpart in germline expression and involves flagellar differentiation. Ju, T.K., Huang, F.L. Biol. Reprod. (2004) [Pubmed]
  11. Circadian pharmacology of L-alanosine (SDX-102) in mice. Li, X.M., Kanekal, S., Crépin, D., Guettier, C., Carrière, J., Elliott, G., Lévi, F. Mol. Cancer Ther. (2006) [Pubmed]
  12. The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells. Porterfield, B.W., Pomykala, H., Maltepe, E., Bohlander, S.K., Rowley, J.D., Diaz, M.O. Somat. Cell Mol. Genet. (1993) [Pubmed]
  13. Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine. Sufrin, J.R., Spiess, A.J., Kramer, D.L., Libby, P.R., Porter, C.W. J. Med. Chem. (1989) [Pubmed]
  14. The comparative effects of 5'-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5'-methylthioadenosine phosphorylase. White, M.W., Riscoe, M.K., Ferro, A.J. Biochim. Biophys. Acta (1983) [Pubmed]
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