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Gene Review

PDC5  -  indolepyruvate decarboxylase 5

Saccharomyces cerevisiae S288c

Synonyms: L3133, L9606.7, Pyruvate decarboxylase isozyme 2, YLR134W
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High impact information on PDC5

  • Mutant studies showed that one of the decarboxylases encoded by PDC1, PDC5, PDC6, YDL080c, or YDR380w must be present to allow yeast to utilize alpha-keto-beta-methylvalerate [1].
  • Thiamine repression and pyruvate decarboxylase autoregulation independently control the expression of the Saccharomyces cerevisiae PDC5 gene [2].
  • We conclude that the stimulation of PDC5 expression in a pdc1delta mutant is not due to a response to thiamine limitation [2].
  • Deletion of either of these genes has little or no effect on the specific pyruvate decarboxylase activity, but enzyme activity is undetectable in mutants lacking both PDC1 and PDC5 (S. Hohmann and H. Cederberg, Eur. J. Biochem. 188:615-621, 1990) [3].
  • A pdc1-8 mutant was used to isolate spontaneous suppressor mutations, which allowed expression of PDC5 [4].

Biological context of PDC5


Associations of PDC5 with chemical compounds

  • Consequently, pdc1 delta pdc5 delta double mutants do not ferment glucose and do not grow on glucose medium [7].
  • Experiments with cell extracts from S. cerevisiae mutants expressing a single PDC gene demonstrated that both PDC1- and PDC5-encoded isoenzymes can decarboxylate branched-chain 2-oxo acids [8].
  • We constructed a metabolically engineered Saccharomyces cerevisiae that has both pyruvate decarboxylase genes (PDC1 and PDC5) disrupted in the genetic background to express two copies of the bovine L-lactate dehydrogenase (LDH) gene [9].

Regulatory relationships of PDC5


Other interactions of PDC5

  • Interestingly, the enzymes Pdc1 and Pdc5 are enriched in the nucleus [10].

Analytical, diagnostic and therapeutic context of PDC5


  1. An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. Dickinson, J.R., Harrison, S.J., Dickinson, J.A., Hewlins, M.J. J. Biol. Chem. (2000) [Pubmed]
  2. Thiamine repression and pyruvate decarboxylase autoregulation independently control the expression of the Saccharomyces cerevisiae PDC5 gene. Muller, E.H., Richards, E.J., Norbeck, J., Byrne, K.L., Karlsson, K.A., Pretorius, G.H., Meacock, P.A., Blomberg, A., Hohmann, S. FEBS Lett. (1999) [Pubmed]
  3. Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae. Hohmann, S. J. Bacteriol. (1991) [Pubmed]
  4. Autoregulation of yeast pyruvate decarboxylase gene expression requires the enzyme but not its catalytic activity. Eberhardt, I., Cederberg, H., Li, H., König, S., Jordan, F., Hohmann, S. Eur. J. Biochem. (1999) [Pubmed]
  5. Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5. Hohmann, S., Cederberg, H. Eur. J. Biochem. (1990) [Pubmed]
  6. Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Hohmann, S. Mol. Gen. Genet. (1993) [Pubmed]
  7. PDC6, a weakly expressed pyruvate decarboxylase gene from yeast, is activated when fused spontaneously under the control of the PDC1 promoter. Hohmann, S. Curr. Genet. (1991) [Pubmed]
  8. Pyruvate decarboxylase catalyzes decarboxylation of branched-chain 2-oxo acids but is not essential for fusel alcohol production by Saccharomyces cerevisiae. ter Schure, E.G., Flikweert, M.T., van Dijken, J.P., Pronk, J.T., Verrips, C.T. Appl. Environ. Microbiol. (1998) [Pubmed]
  9. The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production. Ishida, N., Saitoh, S., Onishi, T., Tokuhiro, K., Nagamori, E., Kitamoto, K., Takahashi, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  10. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita, D., Hohmann, S. Mol. Genet. Genomics (2006) [Pubmed]
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