The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NOP56  -  snoRNP complex protein NOP56

Saccharomyces cerevisiae S288c

Synonyms: L8167.9, Nucleolar protein 56, Ribosome biosynthesis protein SIK1, SIK1, Suppressor of I kappa b protein 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SIK1

  • Here we report that Nop56p, a protein related in sequence to Nop58p, is a bona fide box C+D snoRNP component; all tested box C+D snoRNAs were coprecipitated with protein A-tagged Nop56p [1].
  • Analysis of in vivo snoRNP assembly indicated that Nop56p was stably associated with the snoRNAs only in the presence of Nop1p [1].
  • In addition, SIK1 fails to partition the apical cell; thus, nuclei are not likely to arrest mitosis in interphase as in normal cells, but continue to divide, accumulating to high levels [2].
  • We found that over-expression of HXT11 (which encodes a plasma membrane transporter), PPE1 (coding for a protein methyl esterase), or SIK1 (which encodes a protein involved in rRNA processing) shortened the duration of the G1 phase of the cell cycle, prior to the initiation of DNA replication [3].
  • Mapping the 5' end of X. laevis Nop56 transcript indicates that it starts with a pyrimidine tract and the analysis of genomic clones revealed a snoRNA encoded in one of NOP56 introns [4].

Biological context of SIK1


Associations of SIK1 with chemical compounds

  • Drosophila Nop56p proteins contain lysine-rich regions at their carboxy-terminus, and show a high degree of similarity to other Nop56p proteins from different organisms [7].


  1. Synthesis and assembly of the box C+D small nucleolar RNPs. Lafontaine, D.L., Tollervey, D. Mol. Cell. Biol. (2000) [Pubmed]
  2. Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulans. Han, K.H., Prade, R.A. Mol. Microbiol. (2002) [Pubmed]
  3. A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya, L.M., Pathak, R., Cham, R., Guo, J., Surovtseva, Y.V., Jaeckel, L., Polymenis, M. Curr. Genet. (2004) [Pubmed]
  4. Characterization of the sequences encoding for Xenopus laevis box C/D snoRNP Nop56 protein. Renzi, F., Filippini, D., Loreni, F., Bozzoni, I., Caffarelli, E. Biochim. Biophys. Acta (2002) [Pubmed]
  5. Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. Wu, P., Brockenbrough, J.S., Metcalfe, A.C., Chen, S., Aris, J.P. J. Biol. Chem. (1998) [Pubmed]
  6. Two MAR DNA-binding proteins of the pea nuclear matrix identify a new class of DNA-binding proteins. Hatton, D., Gray, J.C. Plant J. (1999) [Pubmed]
  7. Dnop56, a Drosophila gene homologous to the yeast nucleolar NOP56 gene. García-Planells, J., Paricio, N., Palau, F., de Frutos, R. Genetica (2000) [Pubmed]
WikiGenes - Universities