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Gene Review:

HXT11 - Hxt11p

Saccharomyces cerevisiae S288c

Synonyms: AOB567, Hexose transporter HXT11, LGT3, Low-affinity glucose transporter LGT3, O0414, ...

Bogomolnaya, L.M. et al., Nourani, A. et al.

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High impact information on HXT11

Loss of HXT11 and/or HXT9 confers cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistance [1].
In this study, we show that the HXT11 product, which allows glucose uptake in a glucose permease mutant (rag1) strain of Kluyveromyces lactis, is also involved in the pleiotropic drug resistance process [1].
We found that over-expression of HXT11 (which encodes a plasma membrane transporter), PPE1 (coding for a protein methyl esterase), or SIK1 (which encodes a protein involved in rRNA processing) shortened the duration of the G1 phase of the cell cycle, prior to the initiation of DNA replication [2].
Thus, unlike HXT11 and PPE1, SIK1 over-expression is also associated with mitotic functions [2].

References

Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Nourani, A., Wesolowski-Louvel, M., Delaveau, T., Jacq, C., Delahodde, A. Mol. Cell. Biol. (1997) [Pubmed]
A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya, L.M., Pathak, R., Cham, R., Guo, J., Surovtseva, Y.V., Jaeckel, L., Polymenis, M. Curr. Genet. (2004) [Pubmed]

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AGOS_AFL204C	Ashbya gossypii ATCC 10895
MGG_00040	Magnaporthe oryzae 70-15
NCU05627	Neurospora crassa OR74A
HXT4	Saccharomyces cerevisiae S288c
HXT3	Saccharomyces cerevisiae S288c
GAL2	Saccharomyces cerevisiae S288c
HXT8	Saccharomyces cerevisiae S288c
HXT9	Saccharomyces cerevisiae S288c
HXT1	Saccharomyces cerevisiae S288c
HXT7	Saccharomyces cerevisiae S288c
HXT6	Saccharomyces cerevisiae S288c
ght4	Schizosaccharomyces pombe 972h-
ght1	Schizosaccharomyces pombe 972h-
ght2	Schizosaccharomyces pombe 972h-
ght5	Schizosaccharomyces pombe 972h-
ght6	Schizosaccharomyces pombe 972h-
ght8	Schizosaccharomyces pombe 972h-
ght3	Schizosaccharomyces pombe 972h-
ght7	Schizosaccharomyces pombe 972h-

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