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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Population Density

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Disease relevance of Population Density


High impact information on Population Density

  • Polygyny may also contribute, but the reduction of variation within populations that we measure for the Y chromosome, relative to the autosomes and mitochondrial DNA, is of such magnitude that differences in the effective population sizes of the sexes alone are insufficient to produce the observation [6].
  • Mucin degradation in human colon ecosystems. Fecal population densities of mucin-degrading bacteria estimated by a "most probable number" method [7].
  • The requirement of each hematopoietic sub-population for a specific sub-set of survival factors, provides a flexible mechanism for dictating the cellular composition of the mature population and for controlling population size [8].
  • We show (i) that initial land degradation was caused by settlement, not by agriculture; (ii) that population density inversely correlates with erosion; and (iii) that land degradation was associated with European Conquest but not from the introduction of the Euro-agro suite [9].
  • Comparisons with mtDNA ND2 sequences from some of the same individuals revealed a larger female versus male effective population size for chimpanzees [10].

Chemical compound and disease context of Population Density


Biological context of Population Density


Anatomical context of Population Density


Associations of Population Density with chemical compounds

  • We find that the physical layout of nodes form a fractal set, determined by population density patterns around the globe [26].
  • Under the conditions of high population density and low calf serum concentration used in the assay for transformed focus formation, the transformed or neoplastic cells were much more sensitive to killing by methotrexate (MTX) than were non-neoplastic cells in the same culture [27].
  • During the deceleratory phase, the equilibrium growth rate of C6 cells is a monotonically decreasing function of population density at all observable densities, whether sub- or supraconfluent [28].
  • The epidermis on the backs or ears of DBA/2 mice treated for 7 days with a 20% concentration of monobenzyl ether of hydroquinone (MBEH) had a significantly greater population density of ATPase- and Ia-positive cells compared with control mice treated with diluent [29].
  • In a group of hypercholesterolemic patients (n = 19), high density lipoprotein cholesterol levels were negatively correlated to the population size of CD64-CD16+ monocytes [30].

Gene context of Population Density

  • This was evidenced by the ability of all but the smallest population-size treatments to maintain relatively high levels of mean fitness even under the 100-fold increase in mutational pressure caused by knocking out the msh-2 gene [31].
  • These results suggest that CD4-CD8-CD44+ IL-2R+ thymocytes express Fas and there is overpopulation of the subsequent developmental stage of thymocytes in Fas mutant lpr mice [32].
  • Based on the relative decrease in the number of CFU-GM in the op/op mice, it appears that the population size of these progenitors is less dependent on CSF-1 than the hematopoietic stem cell population size as evidenced by the day-11 CFU-S assay [33].
  • The contribution of BRCA1 and BRCA2 mutations in breast cancer populations, unselected for age and family history, has been examined in several studies reporting mutation frequencies between 1% and 12% by screening methods, population sizes, and to what extent the gene/s were screened differed in the studies [34].
  • It was shown that the constitutive acid phosphatase (PHO3 gene product) is mainly transported to the cell surface by a lower density population of vesicles, while the repressible acid phosphatase (a heteromer encoded by PHO5, PHO10, and PHO11 genes) by a vesicle population of higher density [35].

Analytical, diagnostic and therapeutic context of Population Density


  1. Population density alters the responsiveness of GH4C1 pituitary tumor cells to 17 beta-estradiol. Shull, J.D. Endocrinology (1991) [Pubmed]
  2. Conditional suicide system of Escherichia coli released into soil that uses the Bacillus subtilis sacB gene. Recorbet, G., Robert, C., Givaudan, A., Kudla, B., Normand, P., Faurie, G. Appl. Environ. Microbiol. (1993) [Pubmed]
  3. Mycobacterium diversity and pyrene mineralization in petroleum-contaminated soils. Cheung, P.Y., Kinkle, B.K. Appl. Environ. Microbiol. (2001) [Pubmed]
  4. Protein deficiency impairs erythropoiesis in rats by reducing serum erythropoietin concentration and the population size of erythroid precursor cells. Okano, M., Ohnota, H., Sasaki, R. J. Nutr. (1992) [Pubmed]
  5. Characteristics of spontaneously proliferating mononuclear cells in rheumatoid arthritis. Froebel, K., Dickson, R., Lewis, D., Jasani, M.K., Sturrock, R.D. Ann. Rheum. Dis. (1984) [Pubmed]
  6. Genetic evidence for a higher female migration rate in humans. Seielstad, M.T., Minch, E., Cavalli-Sforza, L.L. Nat. Genet. (1998) [Pubmed]
  7. Mucin degradation in human colon ecosystems. Fecal population densities of mucin-degrading bacteria estimated by a "most probable number" method. Miller, R.S., Hoskins, L.C. Gastroenterology (1981) [Pubmed]
  8. Functional aspects of apoptosis in hematopoiesis and consequences of failure. McKenna, S.L., Cotter, T.G. Adv. Cancer Res. (1997) [Pubmed]
  9. A reexamination of human-induced environmental change within the Lake Pátzcuaro Basin, Michoacán, Mexico. Fisher, C.T., Pollard, H.P., Israde-Alcántara, I., Garduño-Monroy, V.H., Banerjee, S.K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. High levels of Y-chromosome nucleotide diversity in the genus Pan. Stone, A.C., Griffiths, R.C., Zegura, S.L., Hammer, M.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. The apparent clock-like evolution of Escherichia coli in glucose-limited chemostats is reproducible at large but not at small population sizes and can be explained with Monod kinetics. Wick, L.M., Weilenmann, H., Egli, T. Microbiology (Reading, Engl.) (2002) [Pubmed]
  12. Competitive and interactions affecting a fermentative spirochete in anaerobic chemostats. Dollhopf, S.L., Pariseau, M.L., Hashsham, S.A., Tiedje, J.M. Microb. Ecol. (2003) [Pubmed]
  13. Factors affecting the survival and growth of bacteria introduced into lake water. Scheuerman, P.R., Schmidt, J.P., Alexander, M. Arch. Microbiol. (1988) [Pubmed]
  14. Identification and enumeration of oleic acid and linoleic acid hydrating bacteria in the rumen of sheep and cows. Hudson, J.A., Cai, Y., Corner, R.J., Morvan, B., Joblin, K.N. J. Appl. Microbiol. (2000) [Pubmed]
  15. The microbial content and complement C3 cleaving capacity of comedones in acne vulgaris. Leeming, J.P., Ingham, E., Cunliffe, W.J. Acta Derm. Venereol. (1988) [Pubmed]
  16. Acyl homoserine-lactone quorum-sensing signal generation. Parsek, M.R., Val, D.L., Hanzelka, B.L., Cronan, J.E., Greenberg, E.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Relative mutation rates at di-, tri-, and tetranucleotide microsatellite loci. Chakraborty, R., Kimmel, M., Stivers, D.N., Davison, L.J., Deka, R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Amino acid substitution at the Adh locus of Drosophila is facilitated by small population size. Ohta, T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. Figarella, K., Rawer, M., Uzcategui, N.L., Kubata, B.K., Lauber, K., Madeo, F., Wesselborg, S., Duszenko, M. Cell Death Differ. (2005) [Pubmed]
  20. Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital. de Leon, J., Barnhill, J., Rogers, T., Boyle, J., Chou, W.H., Wedlund, P.J. The American journal of psychiatry. (1998) [Pubmed]
  21. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Kaetzel, C.S., Robinson, J.K., Chintalacharuvu, K.R., Vaerman, J.P., Lamm, M.E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Mora, A.L., Corn, R.A., Stanic, A.K., Goenka, S., Aronica, M., Stanley, S., Ballard, D.W., Joyce, S., Boothby, M. Cell Death Differ. (2003) [Pubmed]
  23. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Zhang, T., Otevrel, T., Gao, Z., Gao, Z., Ehrlich, S.M., Fields, J.Z., Boman, B.M. Cancer Res. (2001) [Pubmed]
  24. Effects of T3R alpha 1 and T3R alpha 2 gene deletion on T and B lymphocyte development. Arpin, C., Pihlgren, M., Fraichard, A., Aubert, D., Samarut, J., Chassande, O., Marvel, J. J. Immunol. (2000) [Pubmed]
  25. HLA-DR antigen expression and lymphocyte subsets in transitional cell carcinoma of the urinary bladder. An immunohistological study on frozen sections. Ioachim-Velogianni, E., Stavropoulos, N.E., Kitsiou, E., Stefanaki, S., Agnantis, N.J. J. Pathol. (1994) [Pubmed]
  26. Modeling the Internet's large-scale topology. Yook, S.H., Jeong, H., Barabasi, A.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Selective killing of preneoplastic and neoplastic cells by methotrexate with leucovorin. Chow, M., Rubin, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Deceleratory growth by a rat glial tumor line in culture. Skehan, P., Friedman, S.J. Cancer Res. (1982) [Pubmed]
  29. Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity. Rheins, L.A., Nordlund, J.J. J. Immunol. (1986) [Pubmed]
  30. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia. Rothe, G., Gabriel, H., Kovacs, E., Klucken, J., Stöhr, J., Kindermann, W., Schmitz, G. Arterioscler. Thromb. Vasc. Biol. (1996) [Pubmed]
  31. Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans. Estes, S., Phillips, P.C., Denver, D.R., Thomas, W.K., Lynch, M. Genetics (2004) [Pubmed]
  32. Kinetics of Fas-induced apoptosis in thymic organ culture. Zhou, T., Fleck, M., Müeller-Ladner, U., Yang, P., Wang, Z., Gay, S., Matsumoto, S., Mountz, J.D. J. Clin. Immunol. (1997) [Pubmed]
  33. CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages. Wiktor-Jedrzejczak, W., Ratajczak, M.Z., Ptasznik, A., Sell, K.W., Ahmed-Ansari, A., Ostertag, W. Exp. Hematol. (1992) [Pubmed]
  34. BRCA1 mutations in a population-based study of breast cancer in Stockholm County. Margolin, S., Werelius, B., Fornander, T., Lindblom, A. Genet. Test. (2004) [Pubmed]
  35. Vesicular transport of extracellular acid phosphatases in yeast Saccharomyces cerevisiae. Blinnikova, E.I., Mirjuschenko, F.L., Shabalin, Y.A., Egorov, S.N. Biochemistry Mosc. (2002) [Pubmed]
  36. Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites. Misawa, K., Tajima, F. Genetics (1997) [Pubmed]
  37. The influence of male parr body size and mate competition on fertilization success and effective population size in Atlantic salmon. Jones, M.W., Hutchings, J.A. Heredity (2001) [Pubmed]
  38. Morphological types of horizontal cell in rodent retinae: a comparison of rat, mouse, gerbil, and guinea pig. Peichl, L., González-Soriano, J. Vis. Neurosci. (1994) [Pubmed]
  39. A survey of 16S rRNA and amoA genes related to autotrophic ammonia-oxidizing bacteria of the beta-subdivision of the class proteobacteria in contaminated groundwater. Ivanova, I.A., Stephen, J.R., Chang, Y.J., Brüggemann, J., Long, P.E., McKinley, J.P., Kowalchuk, G.A., White, D.C., Macnaughton, S.J. Can. J. Microbiol. (2000) [Pubmed]
  40. Effects of natural products on soil organisms and plant health enhancement. Mulawarman, n.u.l.l., Hallmann, J., Bell, D., Kopp-Holtwiesche, B., Sikora, R.A. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2001) [Pubmed]
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