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Gene Review

IPT1  -  inositolphosphotransferase

Saccharomyces cerevisiae S288c

Synonyms: D4405, Inositolphosphotransferase 1, KTI6, MIC2, Mannosyl diphosphorylinositol ceramide synthase, ...
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High impact information on IPT1

  • Strains with a nonfunctional IPT1 allele lacked mannose-(inositol-phosphate)(2)-ceramide in their plasma membranes, bound significantly less DmAMP1 compared with wild-type strains, and were highly resistant to DmAMP1-mediated membrane permeabilization [1].
  • Transcription of the IPT1 gene is responsive to changes in activity of Pdr1p and Pdr3p [2].
  • A screen conducted to find the yeast genes necessary for its fungicidal action identified two novel syringomycin E response genes, SYR3 and SYR4 [3].
  • SYR4 was identified by Tn5 inactivation of genomic library plasmids that complemented a syr4 mutant allele [3].
  • These results show that SKN1, together with IPT1, is involved in sphingolipid biosynthesis in S. cerevisiae [4].

Biological context of IPT1


Anatomical context of IPT1

  • KTI6 is allelic to IPT1, coding for mannosyl-diinositolphospho-ceramide [M(IP)(2)C] synthase, which produces M(IP)(2)C, the major plasma membrane sphingolipid. kti6 membranes lack M(IP)(2)C and sphingolipid mutants that have reduced levels of M(IP)(2)C precursors, including the sphingolipid building block ceramide survive zymocin [5].

Associations of IPT1 with chemical compounds

  • Furthermore, the genes CSG2 and IPT1 were found to be required for normal growth of gas1Delta cells in the presence of 1 M sorbitol [6].
  • The last step in formation of the major sphingolipid in the yeast plasma membrane, mannosyldiinositol phosphorylceramide, is catalyzed by the product of the IPT1 gene, inositol phosphotransferase (Ipt1p) [2].

Other interactions of IPT1

  • Genetic analysis indicates that Kti6 is likely to act upstream of lipid raft proton pump Kti10/Pma1, a previously identified zymocin sensitivity factor [5].


  1. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Thevissen, K., Cammue, B.P., Lemaire, K., Winderickx, J., Dickson, R.C., Lester, R.L., Ferket, K.K., Van Even, F., Parret, A.H., Broekaert, W.F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae. Hallstrom, T.C., Lambert, L., Schorling, S., Balzi, E., Goffeau, A., Moye-Rowley, W.S. J. Biol. Chem. (2001) [Pubmed]
  3. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Stock, S.D., Hama, H., Radding, J.A., Young, D.A., Takemoto, J.Y. Antimicrob. Agents Chemother. (2000) [Pubmed]
  4. SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. Thevissen, K., Idkowiak-Baldys, J., Im, Y.J., Takemoto, J., François, I.E., Ferket, K.K., Aerts, A.M., Meert, E.M., Winderickx, J., Roosen, J., Cammue, B.P. FEBS Lett. (2005) [Pubmed]
  5. Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin. Zink, S., Mehlgarten, C., Kitamoto, H.K., Nagase, J., Jablonowski, D., Dickson, R.C., Stark, M.J., Schaffrath, R. Eukaryotic Cell (2005) [Pubmed]
  6. Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae. Tomishige, N., Noda, Y., Adachi, H., Shimoi, H., Takatsuki, A., Yoda, K. Mol. Genet. Genomics (2003) [Pubmed]
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