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Gene Review

YPR1  -  trifunctional aldehyde reductase/carbonyl...

Saccharomyces cerevisiae S288c

Synonyms: D9481.8, YDR368W
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High impact information on YPR1

  • Optimization involved modulating the two mitochondrial systems and disrupting of unwanted side reactions associated with ATF2, GCY1, and YPR1 gene products [1].
  • We sought to improve the performance of baker's yeast for beta-keto ester reductions by using recombinant DNA techniques to alter the levels of three enzymes known to play important roles in these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; alpha-acetoxy ketone reductase, Gre2p) [2].
  • Increased xylose and arabinose reductase activity was observed in cell extracts for S. cerevisiae overexpressing the GRE3, YPR1 and YJR096w genes [3].
  • Yeast in which the YPR1 gene has been deleted possess 50% lower 2-methylbutyraldehyde reductase activity than the wild-type strain [4].
  • These results, in combination with those obtained with the deletion mutants, suggest that Gre3p, Ypr1p and the protein encoded by YJR096w are capable of xylose and arabinose reduction in S. cerevisiae [3].

Biological context of YPR1


Associations of YPR1 with chemical compounds

  • The ypr1 deletion mutant showed the lowest specific L-arabinose reductase activity in cell extracts, 3.5 mU/mg protein compared with 7.4 mU/mg protein for the parental strain with no deletions, and the lowest rate of arabitol formation in vivo [3].
  • In comparison to other mammalian and yeast aldo-keto reductases, Ypr1p has relatively high affinity for D,L-glyceraldehyde (1.08 mM) and hexanal (0.39 mM), but relatively low affinity for 4-nitrobenzaldehyde (1.07 mM) [4].


  1. Total biosynthesis of hydrocortisone from a simple carbon source in yeast. Szczebara, F.M., Chandelier, C., Villeret, C., Masurel, A., Bourot, S., Duport, C., Blanchard, S., Groisillier, A., Testet, E., Costaglioli, P., Cauet, G., Degryse, E., Balbuena, D., Winter, J., Achstetter, T., Spagnoli, R., Pompon, D., Dumas, B. Nat. Biotechnol. (2003) [Pubmed]
  2. Highly stereoselective reagents for beta-keto ester reductions by genetic engineering of baker's yeast. Rodríguez, S., Kayser, M.M., Stewart, J.D. J. Am. Chem. Soc. (2001) [Pubmed]
  3. Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Träff, K.L., Jönsson, L.J., Hahn-Hägerdal, B. Yeast (2002) [Pubmed]
  4. Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase. Ford, G., Ellis, E.M. Yeast (2002) [Pubmed]
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