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Gene Review

ATF2  -  Atf2p

Saccharomyces cerevisiae S288c

Synonyms: AATase 2, Alcohol O-acetyltransferase 2, G7135, YGR177C
 
 
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Disease relevance of ATF2

 

High impact information on ATF2

  • Lastly, immune complex protein kinase assays, using [gamma-32P]ATP and activating transcription factor 2 (ATF2) as substrates, showed increased p38 MAP kinase activity from LPS-stimulated human neutrophils [2].
  • Analysis of the fermentation products confirmed that the expression levels of ATF1 and ATF2 greatly affect the production of ethyl acetate and isoamyl acetate [3].
  • Disruption of AYR1 eliminated reductive 17betaHSD activity, and expression of CYP7B on the combination background (atf2, ayr1, TRP(+)) permitted efficient (>98%) bioconversion of DHEA to 7alpha-hydroxyDHEA, a product of potential medical utility [4].
  • In TRP(+) atf2 strains DHEA was then converted to androstene-3beta,17beta-diol (A/enediol) by an endogenous 17beta-hydroxysteroid dehydrogenase (17betaHSD) [4].
  • In addition, a toxic effect of pregnenolone linked to the disruption of ATF2 was observed [5].
 

Biological context of ATF2

 

Associations of ATF2 with chemical compounds

 

Other interactions of ATF2

  • Our results suggest that Atf2p (APAT) plays an active role in the detoxification of 3beta-hydroxysteroids in association with the efflux pumps Pdr5p and Snq2p [5].
  • Sli1p has weak similarity to Atf1p and Atf2p, which are alcohol acetyltransferases [9].

References

  1. Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli. Vadali, R.V., Bennett, G.N., San, K.Y. Metab. Eng. (2004) [Pubmed]
  2. Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Nahas, N., Molski, T.F., Fernandez, G.A., Sha'afi, R.I. Biochem. J. (1996) [Pubmed]
  3. Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Verstrepen, K.J., Van Laere, S.D., Vanderhaegen, B.M., Derdelinckx, G., Dufour, J.P., Pretorius, I.S., Winderickx, J., Thevelein, J.M., Delvaux, F.R. Appl. Environ. Microbiol. (2003) [Pubmed]
  4. Dehydroepiandrosterone (DHEA) metabolism in Saccharomyces cerevisiae expressing mammalian steroid hydroxylase CYP7B: Ayr1p and Fox2p display 17beta-hydroxysteroid dehydrogenase activity. Vico, P., Cauet, G., Rose, K., Lathe, R., Degryse, E. Yeast (2002) [Pubmed]
  5. Pregnenolone esterification in Saccharomyces cerevisiae. A potential detoxification mechanism. Cauet, G., Degryse, E., Ledoux, C., Spagnoli, R., Achstetter, T. Eur. J. Biochem. (1999) [Pubmed]
  6. Cloning and nucleotide sequence of the alcohol acetyltransferase II gene (ATF2) from Saccharomyces cerevisiae Kyokai No. 7. Nagasawa, N., Bogaki, T., Iwamatsu, A., Hamachi, M., Kumagai, C. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
  7. Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus. Yoshimoto, H., Fujiwara, D., Momma, T., Tanaka, K., Sone, H., Nagasawa, N., Tamai, Y. Yeast (1999) [Pubmed]
  8. The effect of increased yeast alcohol acetyltransferase and esterase activity on the flavour profiles of wine and distillates. Lilly, M., Bauer, F.F., Lambrechts, M.G., Swiegers, J.H., Cozzolino, D., Pretorius, I.S. Yeast (2006) [Pubmed]
  9. SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast. Momoi, M., Tanoue, D., Sun, Y., Takematsu, H., Suzuki, Y., Suzuki, M., Suzuki, A., Fujita, T., Kozutsumi, Y. Biochem. J. (2004) [Pubmed]
 
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