High impact information on SMP1

• Localization of Smp1 depends on HOG1, and consistently, hog1Delta cells also lose viability during this growth phase [1].
• Phosphorylation of Smp1 by the MAPK is essential for its function, since a mutant allele unable to be phosphorylated by the MAPK displays impaired stress responses [1].
• Deletion mutations of the Rim101p repression targets NRG1 and SMP1 suppress rim101Delta mutant defects in ion tolerance, haploid invasive growth, and sporulation [2].
• Deletion of SMP1 neither causes these phenotypes nor enhances the Rlm1 deletion phenotype [3].
• The open reading frame (ORF) YBR1245 is similar in its N-terminal part to transcription factors like SRF and MCM1 [4].

Biological context of SMP1

• The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae [2].
• One mutation, smp1, confers a respiration-deficient (rho0) phenotype and several Rho- mutants independently isolated by ethidium bromide treatment of the same yeast strain also showed increased stabilities of pSR1 and YRp plasmids [5].

Anatomical context of SMP1

• The wild-type S. cerevisiae cells showed a strongly biased distribution of pSR1 molecules as well as YRp plasmids to the mother cells at mitosis, while the smp1 mutant did not show this bias [5].

Enzymatic interactions of SMP1

• Hog1 phosphorylated Smp1 in vitro at the C-terminal region [1].

Other interactions of SMP1

• Like MEF2A, the yeast proteins Rlm1 and Smp1 exhibit low DNA bending propensities [6].

References