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Gene Review:

RIB1 - GTP cyclohydrolase II

Saccharomyces cerevisiae S288c

Synonyms: GTP cyclohydrolase-2, YBL033C, YBL0417

Heyting, C. et al., Boretsky, Y. et al., Skala, J. et al., Heyting, C. et al., Dujon, B. et al., et al.

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High impact information on RIB1

Sequence analysis reveals four new open reading frames longer than 300 bp: YBL0415 (309 bp), YBL0416 (4539 bp), YBL0417 (1035 bp) and YBL0414 (2115 bp), which extends into the neighbouring 5.2 kb BamHI fragment [1].
Mapping of the RIB1 and RIB7 genes involved in the biosynthesis of riboflavin in Saccharomyces cerevisiae [2].
2. The order of loci, determined in this study, is in agreement with the order deduced from recombination analysis and coretention analysis except for the position of omega+: we conclude that omega+ is located between C321 (RIB-1) and E514 (RIB-3) [3].
The marker C321 (RIB-1) has been localized within a segment of 240 bp which also overlaps the 21S rRNA cistron, and we infer on the basis of indirect evidence that this marker lies within this cistron [3].
In addition, we have constructed a physical map with a resolution of about 200 bp of a HapII fragment of 1850 bp long, which carries the loci omega, RIB-1 and probably RIB-2 [4].

Biological context of RIB1

The chromosomal fragment containing the ARS-like sequence 3' to the RIB1 structural gene, called PgARS, conferred high transformation frequencies of 10(4)-10(5) transformants/microg of DNA to a pUC19-derived plasmid in P. guilliermondii [5].
Mitochondrial DNAs from six p- mutants carrying the genetic locus Rib1 and deleted for the rest of the genome were analyzed [6].

Associations of RIB1 with chemical compounds

1. A series of CS revertants has been selected from various strains (both omega+ and omega-) carrying a CR mitochondrial mutation at the RIB1 locus [7].

Other interactions of RIB1

Partial DNA sequencing of tagged genes showed that they were homologous to the S. cerevisiae genes RIB1, MET2, and SEF1 [8].

Analytical, diagnostic and therapeutic context of RIB1

Molecular cloning of the GTP-cyclohydrolase structural gene RIB1 of Pichia guilliermondii involved in riboflavin biosynthesis [9].

References

The sequence of an 8.8 kb segment on the left arm of chromosome II from Saccharomyces cerevisiae reveals four new open reading frames including homologs of animal DNA polymerase alpha-primases and bacterial GTP cyclohydrolase II. Skala, J., Van Dyck, L., Purnelle, B., Goffeau, A. Yeast (1994) [Pubmed]
Mapping of the RIB1 and RIB7 genes involved in the biosynthesis of riboflavin in Saccharomyces cerevisiae. Buitrago, M.J., Gonzalez, G.A., Saiz, J.E., Revuelta, J.L. Yeast (1993) [Pubmed]
Fine structure of the 21S ribosomal RNA region on yeast mitochondrial DNA. III. Physical location of mitochondrial genetic markers and the molecular nature of omega. Heyting, C., Menke, H.H. Mol. Gen. Genet. (1979) [Pubmed]
Fine structure of the 21S ribosomal RNA region on yeast mitochondria DNA. I. Construction of the physical map and localization of the cistron for the 21S mitochondrial ribosomal RNA. Heyting, C., Meijlink, F.C., Verbeet, M.P., Sanders, J.P., Bos, J.L., Borst, P. Mol. Gen. Genet. (1979) [Pubmed]
Identification of an ARS element and development of a high efficiency transformation system for Pichia guilliermondii. Boretsky, Y., Voronovsky, A., Liuta-Tehlivets, O., Hasslacher, M., Kohlwein, S.D., Shavlovsky, G.M. Curr. Genet. (1999) [Pubmed]
Electron microscopic analysis of the yeast mitochondrial DNA segment conferring chloramphenicol resistance. Lazowska, J. Mol. Gen. Genet. (1979) [Pubmed]
Mitochondrial genetics. XI. Mutations at the mitochondrial locus omega affecting the recombination of mitochondrial genes in Saccharomyces cerevisiae. Dujon, B., Bolotin-Fukuhara, M., Coen, D., Deutsch, J., Netter, P., Slonimski, P.P., Weill, L. Mol. Gen. Genet. (1976) [Pubmed]
Insertion mutagenesis of the yeast Candida famata (Debaryomyces hansenii) by random integration of linear DNA fragments. Dmytruk, K.V., Voronovsky, A.Y., Sibirny, A.A. Curr. Genet. (2006) [Pubmed]
Molecular cloning of the GTP-cyclohydrolase structural gene RIB1 of Pichia guilliermondii involved in riboflavin biosynthesis. Liauta-Teglivets, O., Hasslacher, M., Boretskii, I.u.R., Kohlwein, S.D., Shavlovskii, G.M. Yeast (1995) [Pubmed]

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AGOS_ADL296C	Ashbya gossypii ATCC 10895
KLLA0B12375g	Kluyveromyces lactis NRRL Y-1140
MGG_10689	Magnaporthe oryzae 70-15
NCU07188	Neurospora crassa OR74A
SPAP27G11.09c	Schizosaccharomyces pombe 972h-

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