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Gene Review

EHT1  -  Eht1p

Saccharomyces cerevisiae S288c

Synonyms: Alcohol O-acetyltransferase, Ethanol hexanoyl transferase 1, Medium-chain fatty acid ethyl ester synthase/esterase 2, YBR1239, YBR177C
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High impact information on EHT1

  • In this work, we have investigated the role of a three-member S. cerevisiae gene family with moderately divergent sequences (YBR177c/EHT1, YPL095c/EEB1, and YMR210w) [1].
  • Hence, our results identify Eht1 and Eeb1 as novel acyl-coenzymeA:ethanol O-acyltransferases/esterases, whereas the third family member, Ymr210w, does not seem to play an important role in medium-chain fatty acid ethyl ester formation [1].
  • Overexpression of Eht1 and Eeb1 did not enhance medium-chain fatty acid ethyl ester content, which is probably due to the bifunctional synthesis and hydrolysis activity [1].
  • Purified glutathione S-transferase-tagged Eht1 and Eeb1 proteins both exhibited acyl-coenzymeA:ethanol O-acyltransferase activity in vitro, as well as esterase activity [1].
  • The ATF1- and ATF2-encoded alcohol acetyltransferases of S. cerevisiae are responsible for the synthesis of ethyl acetate and isoamyl acetate esters, while the EHT1-encoded ethanol hexanoyl transferase is responsible for synthesizing ethyl caproate [2].

Biological context of EHT1


Associations of EHT1 with chemical compounds


  1. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. Saerens, S.M., Verstrepen, K.J., Van Laere, S.D., Voet, A.R., Van Dijck, P., Delvaux, F.R., Thevelein, J.M. J. Biol. Chem. (2006) [Pubmed]
  2. The effect of increased yeast alcohol acetyltransferase and esterase activity on the flavour profiles of wine and distillates. Lilly, M., Bauer, F.F., Lambrechts, M.G., Swiegers, J.H., Cozzolino, D., Pretorius, I.S. Yeast (2006) [Pubmed]
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