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Gene Review

MSB2  -  Msb2p

Saccharomyces cerevisiae S288c

Synonyms: Multicopy suppressor of bud emergence 2, Osmosensor MSB2, Signaling mucin MSB2, YGR014W
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Disease relevance of MSB2


High impact information on MSB2

  • Taken together, our data suggest that Msb2 is a signaling mucin that interacts with general components, such as Cdc42 and Sho1, to promote their function in the FG pathway [1].
  • The use of DNA microarrays to monitor gene expression revealed that Sho1 and Msb2 regulate identical gene sets in hog1 mutants [2].
  • MSB2 is located between the centromere and KSS1 on the right arm of chromosome VII [3].
  • MSB2 was identified previously as a multicopy suppressor of a temperature-sensitive mutation in CDC24, a gene required for polarity establishment and bud formation in Saccharomyces cerevisiae [3].
  • Although physical mapping suggests that MSB2 and LEU1 (on the left arm of chromosome VII) are approximately 40 kb apart, the genetic map distance observed between leu1 and an msb2::URA3 marker was only 2.3 cM [3].

Biological context of MSB2


Other interactions of MSB2

  • A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch [2].


  1. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Cullen, P.J., Sabbagh, W., Graham, E., Irick, M.M., van Olden, E.K., Neal, C., Delrow, J., Bardwell, L., Sprague, G.F. Genes Dev. (2004) [Pubmed]
  2. A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. O'Rourke, S.M., Herskowitz, I. Mol. Cell. Biol. (2002) [Pubmed]
  3. A Ser/Thr-rich multicopy suppressor of a cdc24 bud emergence defect. Bender, A., Pringle, J.R. Yeast (1992) [Pubmed]
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