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Gene Review

KSS1  -  mitogen-activated serine/threonine-protein...

Saccharomyces cerevisiae S288c

Synonyms: Kinase suppressor of SST2, MAP kinase KSS1, Mitogen-activated protein kinase KSS1, YGR040W
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Disease relevance of KSS1


High impact information on KSS1

  • The predicted FUS3 protein is 35% identical to the cdc2+/CDC28 kinases and 52% identical to the KSS1 predicted kinase [3].
  • The KSS1 gene encodes an apparent protein kinase homologous to the CDC28 (S. cerevisiae) and cdc2+ (S. pombe) gene products [4].
  • Because SST2 product and the receptor tail contribute independently to events that allow recovery from pheromone-induced growth arrest, KSS1 function defines a third independent process that promotes desensitization [4].
  • Both developmental alternatives to vegetative proliferation require the MAP kinase Kss1 and the transcriptional transactivator Ste12 [5].
  • Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins [6].

Biological context of KSS1

  • This functional redundancy is strain dependent; some standard laboratory strains (S288C) are kss1-. FUS3 has additional functions required for cell cycle arrest and vegetative growth that do not overlap with KSS1 functions [1].
  • Since CEK1 confers a phenotype similar to that of the structurally related S. cerevisiae gene KSS1 but cannot complement a KSS1 defect, it is evident that dominant negative selection can identify proteins that complementation screens would miss [7].
  • MSB2 is located between the centromere and KSS1 on the right arm of chromosome VII [8].
  • Strains isogenic to S288C used in the yeast genome sequencing programme carry a functional KSS1 gene [9].
  • Here, we report evidence that S288C derivatives used in the Yeast Genome Sequencing Programme carry a functional KSS1 gene and can thus be used to study the regulation of gene expression by KSS1 [9].

Other interactions of KSS1

  • Expression of Xenopus MAP kinase suppressed the defect associated with loss of MPK1 but not the mating-related defects associated with loss of FUS3 or KSS1, indicating functional conservation between the former two protein kinases [10].
  • Additionally, the cellular projections formed by a pbs2-3 mutant on high osmolarity are absent in strains lacking KSS1 or STE7 [11].
  • The mutation in KSS1 suppresses the osmolarity-hypersensitive phenotype of the hog1 deletion mutation and restores GPD1 induction [2].


  1. FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Elion, E.A., Brill, J.A., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Osmolarity hypersensitivity of hog1 deleted mutants is suppressed by mutation in KSS1 in budding yeast Saccharomyces cerevisiae. Lee, S.J., Park, S.Y., Na, J.G., Kim, Y.J. FEMS Microbiol. Lett. (2002) [Pubmed]
  3. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Elion, E.A., Grisafi, P.L., Fink, G.R. Cell (1990) [Pubmed]
  4. A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Courchesne, W.E., Kunisawa, R., Thorner, J. Cell (1989) [Pubmed]
  5. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Cook, J.G., Bardwell, L., Kron, S.J., Thorner, J. Genes Dev. (1996) [Pubmed]
  6. Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Bardwell, L., Cook, J.G., Zhu-Shimoni, J.X., Voora, D., Thorner, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest. Whiteway, M., Dignard, D., Thomas, D.Y. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. A Ser/Thr-rich multicopy suppressor of a cdc24 bud emergence defect. Bender, A., Pringle, J.R. Yeast (1992) [Pubmed]
  9. Strains isogenic to S288C used in the yeast genome sequencing programme carry a functional KSS1 gene. Morillon, A., Springer, M., Lesage, P. Curr. Genet. (2001) [Pubmed]
  10. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Lee, K.S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K., Levin, D.E. Mol. Cell. Biol. (1993) [Pubmed]
  11. Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants. Davenport, K.D., Williams, K.E., Ullmann, B.D., Gustin, M.C. Genetics (1999) [Pubmed]
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