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Gene Review

GZF3  -  Gzf3p

Saccharomyces cerevisiae S288c

Synonyms: DEH1, J0806, NIL2, Protein GZF3, YJL110C
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High impact information on GZF3

  • GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes [1].
  • These regions show strong sequence similarity to regulatory proteins from Saccharomyces cerevisiae (Dal80p and Gzf3p), Penicillium chrysogenum (NREB) and Neurospora crassa (ASD4) [2].
  • We further show that Gzf3, another GATA zinc-finger protein, acts as a negative regulator in nitrogen-source control of CIS2 expression [3].
  • Additionally, both Dal80p and Deh1p are predicted to contain a leucine zipper motif near their C termini [4].
  • If Dal80p and Deh1p bind to DNA only after dimerization, then the difference in ability to form complexes could significantly affect their affinity for binding DNA and thus the degree of regulation exerted by each of the two factors [4].

Biological context of GZF3


Associations of GZF3 with chemical compounds

  • Apparently, the principal role of Nil2p is to prevent activation of transcription by Nil1p unless Nil1p has been converted to a more active state by the absence of glutamine and glutamate [7].

Regulatory relationships of GZF3

  • The Uga43p factor negatively regulates GZF3 expression and vice versa [8].

Other interactions of GZF3

  • At least one positive GATA factor is required for the UGA43 and GZF3 genes to be expressed [8].
  • The primary effect of the elimination of Nil2p appears to be an increase in the intracellular level of Nil1p, which in turn is responsible for increased expression of GAP1 [7].


  1. Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae. Cunningham, T.S., Andhare, R., Cooper, T.G. J. Biol. Chem. (2000) [Pubmed]
  2. The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Conlon, H., Zadra, I., Haas, H., Arst, H.N., Jones, M.G., Caddick, M.X. Mol. Microbiol. (2001) [Pubmed]
  3. Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Springael, J.Y., Penninckx, M.J. Biochem. J. (2003) [Pubmed]
  4. The Saccharomyces cerevisiae GATA factors Dal80p and Deh1p can form homo- and heterodimeric complexes. Svetlov, V.V., Cooper, T.G. J. Bacteriol. (1998) [Pubmed]
  5. Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. Coffman, J.A., Rai, R., Loprete, D.M., Cunningham, T., Svetlov, V., Cooper, T.G. J. Bacteriol. (1997) [Pubmed]
  6. The minimal transactivation region of Saccharomyces cerevisiae Gln3p is localized to 13 amino acids. Svetlov, V., Cooper, T.G. J. Bacteriol. (1997) [Pubmed]
  7. Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae. Rowen, D.W., Esiobu, N., Magasanik, B. J. Bacteriol. (1997) [Pubmed]
  8. Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae. Soussi-Boudekou, S., Vissers, S., Urrestarazu, A., Jauniaux, J.C., André, B. Mol. Microbiol. (1997) [Pubmed]
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