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Gene Review

ECM38  -  gamma-glutamyltransferase

Saccharomyces cerevisiae S288c

Synonyms: CIK1 suppressor protein 2, CIS2, Extracellular mutant protein 38, Gamma-GT, Gamma-glutamyltransferase, ...
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High impact information on ECM38

  • During growth on a preferred nitrogen source like NH(4)(+), CIS2 expression is repressed through a mechanism involving (at least) the Gln3-binding protein Ure2/GdhCR [1].
  • We further show that Gzf3, another GATA zinc-finger protein, acts as a negative regulator in nitrogen-source control of CIS2 expression [1].
  • The promoter region of CIS2 contains one stress-response element (CCCCT) and eight GAT(T/A)A core sequences, probably involved in nitrogen-regulated transcription [1].
  • The V(max) (app)-increasing effect of gamma-GT concerns only the YCF1 system. gamma-GT in the vacuolar membrane activates the Ycf1p transporter, either directly or indirectly [2].
  • Excretion of glutamate from radiolabelled GSH in isolated vacuoles containing gamma-GT was also measured [2].

Biological context of ECM38


Anatomical context of ECM38


Associations of ECM38 with chemical compounds


Other interactions of ECM38


  1. Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Springael, J.Y., Penninckx, M.J. Biochem. J. (2003) [Pubmed]
  2. gamma-Glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathione. Mehdi, K., Thierie, J., Penninckx, M.J. Biochem. J. (2001) [Pubmed]
  3. Investigations into the polymorphisms at the ECM38 locus of two widely used Saccharomyces cerevisiae S288C strains, YPH499 and BY4742. Kumar, C., Sharma, R., Bachhawat, A.K. Yeast (2003) [Pubmed]
  4. Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism. He, X., Di, Y., Li, J., Xie, Y., Tang, Y., Zhang, F., Wei, L., Zhang, Y., Qin, W., Huo, K., Li, Y., Wan, D., Gu, J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Glutathione metabolism in relation to the amino-acid permeation systems of the yeast Saccharomyces cerevisiae. Occurrence of gamma-glutamyltranspeptidase: its regulation and the effects of permeation mutations on the enzyme cellular level. Penninckx, M., Jaspers, C., Wiame, J.M. Eur. J. Biochem. (1980) [Pubmed]
  6. Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiae. Elskens, M.T., Jaspers, C.J., Penninckx, M.J. J. Gen. Microbiol. (1991) [Pubmed]
  7. Inhibition of yeast-to-mycelium conversion of Candida albicans by conjugated styryl ketones. Manavathu, E., Duncan, C., Porte, Q., Gunasekaran, M. Mycopathologia (1996) [Pubmed]
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