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Gene Review

NUP100  -  Nup100p

Saccharomyces cerevisiae S288c

Synonyms: NSP100, Nuclear pore protein NUP100/NSP100, Nucleoporin NUP100/NSP100, YKL068W, YKL336
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High impact information on NUP100


Biological context of NUP100


Anatomical context of NUP100


Associations of NUP100 with chemical compounds

  • The deletion of NUP100 allows upf1Delta, can1-100 cells to grow in the presence of canavanine [6].

Physical interactions of NUP100

  • We have previously shown that the GLFG regions of Nup116p and Nup100p directly bind the karyopherin transport factor Kap95p during nuclear protein import [7].

Other interactions of NUP100

  • Finally, we see a genetic interaction between UPF1 and NUP100 [6].


  1. An RNA-export mediator with an essential nuclear export signal. Murphy, R., Wente, S.R. Nature (1996) [Pubmed]
  2. Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p. Bailer, S.M., Siniossoglou, S., Podtelejnikov, A., Hellwig, A., Mann, M., Hurt, E. EMBO J. (1998) [Pubmed]
  3. A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. Iovine, M.K., Wente, S.R. J. Cell Biol. (1997) [Pubmed]
  4. A new family of yeast nuclear pore complex proteins. Wente, S.R., Rout, M.P., Blobel, G. J. Cell Biol. (1992) [Pubmed]
  5. Sequence of a 20.7 kb region of yeast chromosome XI includes the NUP100 gene, an open reading frame (ORF) possibly representing a nucleoside diphosphate kinase gene, tRNAs for His, Val and Trp in addition to seven ORFs with weak or no significant similarity to known proteins. Rasmussen, S.W. Yeast (1994) [Pubmed]
  6. Upf1p, a highly conserved protein required for nonsense-mediated mRNA decay, interacts with the nuclear pore proteins Nup100p and Nup116p. Nazarenus, T., Cedarberg, R., Bell, R., Cheatle, J., Forch, A., Haifley, A., Hou, A., Wanja Kebaara, B., Shields, C., Stoysich, K., Taylor, R., Atkin, A.L. Gene (2005) [Pubmed]
  7. The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. Strawn, L.A., Shen, T., Wente, S.R. J. Biol. Chem. (2001) [Pubmed]
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