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Gene Review

NUP84  -  Nup84p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear pore protein NUP84, Nucleoporin NUP84, YDL116W
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High impact information on NUP84


Biological context of NUP84


Physical interactions of NUP84

  • Moreover, we show that Nup157 and Nup145N bind to the heptameric Nup84 complex [6].
  • Unexpectedly, the same Nups also captured the hexameric Nup84p complex and Nup2p [7].

Other interactions of NUP84


Analytical, diagnostic and therapeutic context of NUP84

  • A highly purified Nup84p complex was isolated from yeast under native conditions and its molecular mass was determined to be 375 kD by quantitative scanning transmission electron microscopy and analytical ultracentrifugation, consistent with a monomeric complex [9].
  • During the sequential reconstitution of the Nup84p complex, smaller assembly intermediates can be isolated, which exhibit modular structures determined by electron microscopy that finally make up the whole Y-shaped Nup84p complex [2].


  1. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Siniossoglou, S., Wimmer, C., Rieger, M., Doye, V., Tekotte, H., Weise, C., Emig, S., Segref, A., Hurt, E.C. Cell (1996) [Pubmed]
  2. Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. Lutzmann, M., Kunze, R., Buerer, A., Aebi, U., Hurt, E. EMBO J. (2002) [Pubmed]
  3. A novel complex of membrane proteins required for formation of a spherical nucleus. Siniossoglou, S., Santos-Rosa, H., Rappsilber, J., Mann, M., Hurt, E. EMBO J. (1998) [Pubmed]
  4. Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Menon, B.B., Sarma, N.J., Pasula, S., Deminoff, S.J., Willis, K.A., Barbara, K.E., Andrews, B., Santangelo, G.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles. Palancade, B., Zuccolo, M., Loeillet, S., Nicolas, A., Doye, V. Mol. Biol. Cell (2005) [Pubmed]
  6. Reconstitution of Nup157 and Nup145N into the Nup84 complex. Lutzmann, M., Kunze, R., Stangl, K., Stelter, P., Tóth, K.F., Böttcher, B., Hurt, E. J. Biol. Chem. (2005) [Pubmed]
  7. Proteomic analysis of nucleoporin interacting proteins. Allen, N.P., Huang, L., Burlingame, A., Rexach, M. J. Biol. Chem. (2001) [Pubmed]
  8. The nuclear pore complex and the DEAD box protein Rat8p/Dbp5p have nonessential features which appear to facilitate mRNA export following heat shock. Rollenhagen, C., Hodge, C.A., Cole, C.N. Mol. Cell. Biol. (2004) [Pubmed]
  9. Structure and assembly of the Nup84p complex. Siniossoglou, S., Lutzmann, M., Santos-Rosa, H., Leonard, K., Mueller, S., Aebi, U., Hurt, E. J. Cell Biol. (2000) [Pubmed]
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