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Gene Review

BUD4  -  Bud4p

Saccharomyces cerevisiae S288c

Synonyms: Bud site selection protein 4, J1905, YJR092W
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High impact information on BUD4

  • We have identified four genes, BUD1-BUD4, necessary for the axial pattern by isolating mutants of alpha cells that do not exhibit this pattern [1].
  • To better understand how Iqg1p influences these processes, we performed a two-hybrid screen and identified the spatial landmark Bud4p as a binding partner [2].
  • Surprisingly, we found that septin dependent processes like cytokinesis and the localization of Bud4p to the neck still occurred in cdc10Delta cells [3].
  • Mutations in BUD3, BUD4, and AXL1 cause a and alpha cells to exhibit the bipolar pattern, indicating that these genes are necessary to specify the axial budding pattern (Chant, J., and I. Herskowitz. 1991. Cell. 65:1203-1212; Fujita, A., C. Oka, Y. Arikawa, T. Katagi, A. Tonouchi, S. Kuhara, and Y. Misumi. 1994. Nature (Lond.). 372:567-570) [4].
  • Interestingly, PHD1 overexpression enhances pseudohyphal growth in a haploid strain that has the diploid polar budding pattern because of a mutation in the BUD4 gene [5].

Biological context of BUD4

  • These observations suggest that Bud4p and Bud3p cooperate to recognize a spatial landmark (the neck filaments) during mitosis and support the hypothesis that they subsequently become a landmark for establishing the axial budding pattern in G1 [4].
  • Int1p, a C. albicans gene product with similarity in its C terminus to Saccharomyces cerevisiae Bud4p, has a role in hyphal morphogenesis [6].
  • One protein not in the GPI-CWP class that was initially described as an adhesin, Int1p, has recently been shown to be similar to Bud4p of Saccharomyces cerevisiae in primary amino acid sequence, in co-localizing with septins and in functioning in bud site selection [7].

Associations of BUD4 with chemical compounds

  • Three of the four known proteins required for axial budding, Bud3p, Bud4p, and Axl2p, were expressed and localized appropriately in glucose-limiting conditions [8].

Other interactions of BUD4


  1. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Chant, J., Herskowitz, I. Cell (1991) [Pubmed]
  2. Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. Osman, M.A., Konopka, J.B., Cerione, R.A. J. Cell Biol. (2002) [Pubmed]
  3. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. Frazier, J.A., Wong, M.L., Longtine, M.S., Pringle, J.R., Mann, M., Mitchison, T.J., Field, C. J. Cell Biol. (1998) [Pubmed]
  4. The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner. Sanders, S.L., Herskowitz, I. J. Cell Biol. (1996) [Pubmed]
  5. Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Gimeno, C.J., Fink, G.R. Mol. Cell. Biol. (1994) [Pubmed]
  6. Candida albicans Int1p interacts with the septin ring in yeast and hyphal cells. Gale, C., Gerami-Nejad, M., McClellan, M., Vandoninck, S., Longtine, M.S., Berman, J. Mol. Biol. Cell (2001) [Pubmed]
  7. Adhesion in Candida spp. Sundstrom, P. Cell. Microbiol. (2002) [Pubmed]
  8. The roles of bud-site-selection proteins during haploid invasive growth in yeast. Cullen, P.J., Sprague, G.F. Mol. Biol. Cell (2002) [Pubmed]
  9. ACE2, CBK1, and BUD4 in budding and cell separation. Voth, W.P., Olsen, A.E., Sbia, M., Freedman, K.H., Stillman, D.J. Eukaryotic Cell (2005) [Pubmed]
  10. Subcellular localization of Axl1, the cell type-specific regulator of polarity. Lord, M., Inose, F., Hiroko, T., Hata, T., Fujita, A., Chant, J. Curr. Biol. (2002) [Pubmed]
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