Gene Review:
LHS1 - Hsp70 family chaperone LHS1
Saccharomyces cerevisiae S288c
Synonyms:
CER1, Heat shock protein 70 homolog LHS1, SSI1, YKL073W, YKL355
- The Hsp70 homologue Lhs1p is involved in a novel function of the yeast endoplasmic reticulum, refolding and stabilization of heat-denatured protein aggregates. Saris, N., Holkeri, H., Craven, R.A., Stirling, C.J., Makarow, M. J. Cell Biol. (1997)
- LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. Tyson, J.R., Stirling, C.J. EMBO J. (2000)
- A microsomal ATP-binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum. Dierks, T., Volkmer, J., Schlenstedt, G., Jung, C., Sandholzer, U., Zachmann, K., Schlotterhose, P., Neifer, K., Schmidt, B., Zimmermann, R. EMBO J. (1996)
- Cer1p functions as a molecular chaperone in the endoplasmic reticulum of Saccharomyces cerevisiae. Hamilton, T.G., Norris, T.B., Tsuruda, P.R., Flynn, G.C. Mol. Cell. Biol. (1999)
- SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum. Baxter, B.K., James, P., Evans, T., Craig, E.A. Mol. Cell. Biol. (1996)
- Coordinated activation of Hsp70 chaperones. Steel, G.J., Fullerton, D.M., Tyson, J.R., Stirling, C.J. Science (2004)
- The cytoplasmic chaperone hsp104 is required for conformational repair of heat-denatured proteins in the yeast endoplasmic reticulum. Hänninen, A.L., Simola, M., Saris, N., Makarow, M. Mol. Biol. Cell (1999)
- Regulation and recovery of functions of Saccharomyces cerevisiae chaperone BiP/Kar2p after thermal insult. Seppä, L., Makarow, M. Eukaryotic Cell (2005)