Gene Review:
GCN3 - translation initiation factor eIF2B...
Saccharomyces cerevisiae S288c
Synonyms:
AAS2, GCD complex subunit GCN3, Guanine nucleotide exchange factor subunit GCN3, TIF221, Transcriptional activator GCN3, ...
- Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. Yang, W., Hinnebusch, A.G. Mol. Cell. Biol. (1996)
- eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Pavitt, G.D., Ramaiah, K.V., Kimball, S.R., Hinnebusch, A.G. Genes Dev. (1998)
- Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B. Flowers, K.M., Kimball, S.R., Feldhoff, R.C., Hinnebusch, A.G., Jefferson, L.S. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation. Vazquez de Aldana, C.R., Dever, T.E., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Dever, T.E., Chen, J.J., Barber, G.N., Cigan, A.M., Feng, L., Donahue, T.F., London, I.M., Katze, M.G., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Bushman, J.L., Foiani, M., Cigan, A.M., Paddon, C.J., Hinnebusch, A.G. Mol. Cell. Biol. (1993)
- A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Hinnebusch, A.G. Mol. Cell. Biol. (1985)
- gcd12 mutations are gcn3-dependent alleles of GCD2, a negative regulator of GCN4 in the general amino acid control of Saccharomyces cerevisiae. Paddon, C.J., Hinnebusch, A.G. Genetics (1989)
- Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci. Walsh, D.W., Wolfe, K.H., Butler, G. Yeast (2002)
- Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function. Hannig, E.M., Hinnebusch, A.G. Mol. Cell. Biol. (1988)
- Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast. Palmer, L.K., Shoemaker, J.L., Baptiste, B.A., Wolfe, D., Keil, R.L. Mol. Biol. Cell (2005)
- Complex formation by positive and negative translational regulators of GCN4. Cigan, A.M., Foiani, M., Hannig, E.M., Hinnebusch, A.G. Mol. Cell. Biol. (1991)
- Interactions between positive and negative regulators of GCN4 controlling gene expression and entry into the yeast cell cycle. Harashima, S., Hannig, E.M., Hinnebusch, A.G. Genetics (1987)
- Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition. Paddon, C.J., Hannig, E.M., Hinnebusch, A.G. Genetics (1989)
- Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Harashima, S., Hinnebusch, A.G. Mol. Cell. Biol. (1986)
- The protein kinase Gcn2p mediates sodium toxicity in yeast. Goossens, A., Dever, T.E., Pascual-Ahuir, A., Serrano, R. J. Biol. Chem. (2001)