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Gene Review

GPD2  -  glycerol-3-phosphate dehydrogenase...

Saccharomyces cerevisiae S288c

Synonyms: GPD3, O1222, YOL059W
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Disease relevance of GPD2

  • This was done by deletion of GPD1 and GPD2, encoding two isoenzymes of glycerol 3-phosphate dehydrogenase, and expression of a cytoplasmic transhydrogenase from Azotobacter vinelandii, encoded by cth [1].

High impact information on GPD2

  • In the mutant, Deltagpd1/gpd2, lacking glycerol biosynthesis, the stress response was magnified with a partially different set of up-regulated ORFs [2].
  • Deletion of the aldehyde dehydrogenase gene, ALD6, in wild-type and GPD2 overexpressing strains (GPD2-OP) decreased acetic acid production by three- and four-fold, respectively [3].
  • At high demand for NADH reoxidation, a strong induction was seen not only of the GPD2 gene, but also of GPP1, encoding one of the molecular forms of glycerol-3-phosphatase [4].
  • NAD(+)-dependent glycerol-3-phosphate dehydrogenase in S. cerevisiae is present in two isoforms, coded for by two different genes, GPD1 and GPD2 [4].
  • In anaerobic batch fermentations of strain TN5 (gpd2-Delta1), formation of glycerol was significantly impaired, which resulted in reduction of the maximum specific growth rate from 0.41/h in the wild-type to 0.08/h. Deletion of GPD2 also resulted in a reduced biomass yield, but did not affect formation of the remaining products [1].

Analytical, diagnostic and therapeutic context of GPD2

  • The results of Northern blot analysis of GPD genes (GPD1 and GPD2) encoding the GPDH enzyme showed that the transcription of GPD genes was not affected by heat-shock treatment but the period of intensive transcription of GPD1 was prolonged [5].


  1. Anaerobic and aerobic batch cultivations of Saccharomyces cerevisiae mutants impaired in glycerol synthesis. Nissen, T.L., Hamann, C.W., Kielland-Brandt, M.C., Nielsen, J., Villadsen, J. Yeast (2000) [Pubmed]
  2. Transcript expression in Saccharomyces cerevisiae at high salinity. Yale, J., Bohnert, H.J. J. Biol. Chem. (2001) [Pubmed]
  3. Decreasing acetic acid accumulation by a glycerol overproducing strain of Saccharomyces cerevisiae by deleting the ALD6 aldehyde dehydrogenase gene. Eglinton, J.M., Heinrich, A.J., Pollnitz, A.P., Langridge, P., Henschke, P.A., de Barros Lopes, M. Yeast (2002) [Pubmed]
  4. Microaerobic glycerol formation in Saccharomyces cerevisiae. Costenoble, R., Valadi, H., Gustafsson, L., Niklasson, C., Franzén, C.J. Yeast (2000) [Pubmed]
  5. Enhanced glycerol production in Shochu yeast by heat-shock treatment is due to prolonged transcription of GPD1. Kajiwara, Y., Ogawa, K., Takashita, H., Omori, T. J. Biosci. Bioeng. (2000) [Pubmed]
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