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SMC5  -  DNA repair ATPase SMC5

Saccharomyces cerevisiae S288c

Synonyms: Structural maintenance of chromosomes protein 5, YOL034W
 
 
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High impact information on SMC5

  • Altogether this shows that the complex maintains genomic integrity in multiple ways, and evidence is presented that the Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures [1].
  • The chromosomal localization of the budding yeast Smc5/6 complex determined here reveals that the complex works specifically on the duplicated genome in differently regulated pathways [1].
  • SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions [2].
  • The Smc5-Smc6 complex is required for DNA repair, as well as having another essential but enigmatic function [2].
  • Structure chromosome (SMC) proteins organize the core of cohesin, condensin and Smc5-Smc6 complexes [2].
 

Biological context of SMC5

  • Consistent with a requirement for the segregation of repetitive regions, Smc5 and Smc6 proteins are enriched at ribosomal DNA (rDNA) and at some telomeres [2].
  • These results point towards a role for the Smc5-Smc6 complex in preventing the formation of sister chromatid junctions, thereby ensuring the correct partitioning of chromosomes during anaphase [2].
  • A key role for Nse4 in Smc5/6 function is likely, as overexpressing known subunits of the Smc5/6 complex suppresses nse4(ts) cell cycle arrest [3].
  • Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks [4].
  • These findings suggest that the Smc5/6 complex is regulated during the cell cycle, presumably in anticipation of DNA damage that may arise during replication [4].
 

Physical interactions of SMC5

  • Nse2 binds to the middle of the coiled-coil region of Smc5 [5].
 

Regulatory relationships of SMC5

  • Removal of Rad52p or overexpression of the SUMO ligase Mms21p partially suppresses the temperature sensitivity of smc5 strains and increases their survival at the restrictive temperature [6].
 

Other interactions of SMC5

References

  1. Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Lindroos, H.B., Ström, L., Itoh, T., Katou, Y., Shirahige, K., Sjögren, C. Mol. Cell (2006) [Pubmed]
  2. SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Torres-Rosell, J., Machín, F., Farmer, S., Jarmuz, A., Eydmann, T., Dalgaard, J.Z., Aragón, L. Nat. Cell Biol. (2005) [Pubmed]
  3. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Hu, B., Liao, C., Millson, S.H., Mollapour, M., Prodromou, C., Pearl, L.H., Piper, P.W., Panaretou, B. Mol. Microbiol. (2005) [Pubmed]
  4. Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks. Tsuyama, T., Inou, K., Seki, M., Seki, T., Kumata, Y., Kobayashi, T., Kimura, K., Hanaoka, F., Enomoto, T., Tada, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. Duan, X., Yang, Y., Chen, Y.H., Arenz, J., Rangi, G.K., Zhao, X., Ye, H. J. Biol. Chem. (2009) [Pubmed]
  6. Smc5p Promotes Faithful Chromosome Transmission and DNA Repair in Saccharomyces cerevisiae. Cost, G.J., Cozzarelli, N.R. Genetics (2006) [Pubmed]
  7. A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Zhao, X., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Kre29p is a novel nuclear protein involved in DNA repair and mitotic fidelity in Candida glabrata. Miyazaki, T., Tsai, H.F., Bennett, J.E. Curr. Genet. (2006) [Pubmed]
 
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