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Gene Review:

SMC6 - DNA repair protein SMC6

Saccharomyces cerevisiae S288c

Synonyms: DNA repair protein RHC18, L3502.2, RHC18, Rad18 homolog, Structural maintenance of chromosomes protein 6, ...

Torres-Rosell, J. et al., Onoda, F. et al., Torres-Rosell, J. et al., Miyazaki, T. et al., Lehmann, A.R. et al.

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High impact information on SMC6

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions [1].
These results point towards a role for the Smc5-Smc6 complex in preventing the formation of sister chromatid junctions, thereby ensuring the correct partitioning of chromosomes during anaphase [1].
The Smc5-Smc6 complex is required for DNA repair, as well as having another essential but enigmatic function [1].
Structure chromosome (SMC) proteins organize the core of cohesin, condensin and Smc5-Smc6 complexes [1].
Gene deletion shows that both rad18 and RHC18 are essential for proliferation [2].

Biological context of SMC6

SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae [3].
Consistent with a requirement for the segregation of repetitive regions, Smc5 and Smc6 proteins are enriched at ribosomal DNA (rDNA) and at some telomeres [1].
Here, we present results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome [4].
SMC6 (RHC18) in Saccharomyces cerevisiae, which is a homologue of the Schizosaccharomyces pombe rad18+ gene and essential for cell viability, encodes a structural maintenance of chromosomes (SMC) family protein [3].

Physical interactions of SMC6

Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae [4].

Other interactions of SMC6

S. cerevisiae Kre29p has been identified by affinity purification as a subunit of the Smc5-Smc6 complex, which is required for DNA repair and chromosome segregation [5].

References

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Torres-Rosell, J., Machín, F., Farmer, S., Jarmuz, A., Eydmann, T., Dalgaard, J.Z., Aragón, L. Nat. Cell Biol. (2005) [Pubmed]
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. Lehmann, A.R., Walicka, M., Griffiths, D.J., Murray, J.M., Watts, F.Z., McCready, S., Carr, A.M. Mol. Cell. Biol. (1995) [Pubmed]
SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. Onoda, F., Takeda, M., Seki, M., Maeda, D., Tajima, J., Ui, A., Yagi, H., Enomoto, T. DNA Repair (Amst.) (2004) [Pubmed]
Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae. Torres-Rosell, J., Machin, F., Aragón, L. Cell Cycle (2005) [Pubmed]
Kre29p is a novel nuclear protein involved in DNA repair and mitotic fidelity in Candida glabrata. Miyazaki, T., Tsai, H.F., Bennett, J.E. Curr. Genet. (2006) [Pubmed]

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AGOS_AER044W	Ashbya gossypii ATCC 10895
smc6	Danio rerio
KLLA0E05303g	Kluyveromyces lactis NRRL Y-1140
LOC699570	Macaca mulatta
MGG_15281	Magnaporthe oryzae 70-15
NCU02402	Neurospora crassa OR74A
smc6	Schizosaccharomyces pombe 972h-

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