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Gene Review

RPIA  -  ribose 5-phosphate isomerase A

Homo sapiens

Synonyms: Phosphoriboisomerase, RPI, Ribose-5-phosphate isomerase
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Disease relevance of RPIA


High impact information on RPIA


Biological context of RPIA


Anatomical context of RPIA


Associations of RPIA with chemical compounds


Other interactions of RPIA


Analytical, diagnostic and therapeutic context of RPIA

  • The relative three-dimensional co-location of RNA polymerase I (RPI) and DNA was studied using confocal laser scanning microscopy during interphase and all the steps of mitosis in human cancerous cells [8].
  • We evaluated the in vivo activity and the diffusion of radiolabelled RP 57669 (RPI) and RP 54476 (RPII), the two components of the injectable streptogramin RP 59500, alone or in combination, in aortic vegetations from experimental endocarditis in rabbits [2].
  • Via PCR with degenerate primers designed against microsequenced peptides, a hybridisation probe was obtained and used to isolate several cDNA clones which encode RPI [12].
  • In direct-binding radioimmunoassay (RIA), affinity-purified anti-normal rabbit (NR) Fab autoAb cross-reacted with normal mouse (NM) Fab, ssDNA (but not dsDNA), poly(dA,dT), and RNA polymerase I (RPI) [20].
  • Change in cardiovascular response pattern as a function of these activities, as well as the influence of a series of moderator variables on cardiovascular response, was assessed by examining heart rate (HR) and the EKG R-wave to ear pulse interval (RPI) relative to a pre-session baseline [21].


  1. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Huck, J.H., Verhoeven, N.M., Struys, E.A., Salomons, G.S., Jakobs, C., van der Knaap, M.S. Am. J. Hum. Genet. (2004) [Pubmed]
  2. In vivo activities and penetration of the two components of the streptogramin RP 59500 in cardiac vegetations of experimental endocarditis. Fantin, B., Leclercq, R., Ottaviani, M., Vallois, J.M., Maziere, B., Duval, J., Pocidalo, J.J., Carbon, C. Antimicrob. Agents Chemother. (1994) [Pubmed]
  3. Evidence for the presence of phosphoriboisomerase and ribulose-1,5-diphosphate carboxylase in extracts of Desulfovibrio vulgaris. Alvarez, M., Barton, L.L. J. Bacteriol. (1977) [Pubmed]
  4. Usefulness of cyclosporine A on rapidly progressive interstitial pneumonia in dermatomyositis. Miyake, S., Ohtani, Y., Sawada, M., Inase, N., Miyazaki, Y., Takano, S., Miyasaka, N., Yoshizawa, Y. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2002) [Pubmed]
  5. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz, C., Steavenson, S. J. Biol. Chem. (1988) [Pubmed]
  6. Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts. Boss, G.R., Pilz, R.B. J. Biol. Chem. (1985) [Pubmed]
  7. Inhibition of ribose-5-phosphate isomerase by 4-phosphoerythronate. Woodruff, W.W., Wolfenden, R. J. Biol. Chem. (1979) [Pubmed]
  8. Three-dimensional co-location of RNA polymerase I and DNA during interphase and mitosis by confocal microscopy. Gilbert, N., Lucas, L., Klein, C., Menager, M., Bonnet, N., Ploton, D. J. Cell. Sci. (1995) [Pubmed]
  9. IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains. Lefranc, M.P., Pommié, C., Kaas, Q., Duprat, E., Bosc, N., Guiraudou, D., Jean, C., Ruiz, M., Da Piédade, I., Rouard, M., Foulquier, E., Thouvenin, V., Lefranc, G. Dev. Comp. Immunol. (2005) [Pubmed]
  10. IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN. Lefranc, M.P., Duprat, E., Kaas, Q., Tranne, M., Thiriot, A., Lefranc, G. Dev. Comp. Immunol. (2005) [Pubmed]
  11. Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE). Spencer, N., Hopkinson, D.A. Ann. Hum. Genet. (1980) [Pubmed]
  12. Microsequencing and cDNA cloning of the Calvin cycle/OPPP enzyme ribose-5-phosphate isomerase (EC from spinach chloroplasts. Martin, W., Henze, K., Kellerman, J., Flechner, A., Schnarrenberger, C. Plant Mol. Biol. (1996) [Pubmed]
  13. Immunophenotypic discrepancies between granulocytic and erythroid lineages in peripheral blood of patients with paroxysmal nocturnal haemoglobinuria. Pakdeesuwan, K., Wanachiwanawin, W., Siripanyaphinyo, U., Pattanapanyasat, K., Wilairat, P., Issaragrisil, S. Eur. J. Haematol. (2000) [Pubmed]
  14. Immunocytogenetics: localization of transcriptionally active rRNA genes in nucleoli and nucleolus organizer regions by use of human autoantibodies to RNA polymerase I. Haaf, T., Reimer, G., Schmid, M. Cytogenet. Cell Genet. (1988) [Pubmed]
  15. Pain intensity in nondiabetic patients with myocardial infarction or unstable angina. Its association with clinical and psychological features. Tsouna-Hadjis, E., Kallergis, G., Agrios, N., Zakopoulos, N., Lyropoulos, S., Liakos, A., Sideris, D., Stamatelopoulos, S. International journal of cardiology. (1998) [Pubmed]
  16. The association of ribulose-1,5-bisphosphate carboxylase with phosphoriboisomerase and phosphoribulokinase. Sainis, J.K., Harris, G.C. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  17. Analysis of phosphorus herbicides by ion-pairing reversed-phase liquid chromatography coupled to inductively coupled plasma mass spectrometry with octapole reaction cell. Sadi, B.B., Vonderheide, A.P., Caruso, J.A. Journal of chromatography. A. (2004) [Pubmed]
  18. Separation of parent benzodiazepines and their major metabolites by reverse-phase ion-pair chromatography. Sohr, C.J., Buechel, A.T. Journal of analytical toxicology. (1982) [Pubmed]
  19. Analysis of polyols in urine by liquid chromatography-tandem mass spectrometry: a useful tool for recognition of inborn errors affecting polyol metabolism. Wamelink, M.M., Smith, D.E., Jakobs, C., Verhoeven, N.M. J. Inherit. Metab. Dis. (2005) [Pubmed]
  20. Induction of an anti-Fab, anti-DNA and anti-RNA polymerase I autoantibody response network in rabbits immunized with SLE anti-DNA antibody. Rombach, E., Stetler, D.A., Brown, J.C. Clin. Exp. Immunol. (1993) [Pubmed]
  21. Cardiovascular response patterns and speech: a study of air traffic controllers. Henderson, P.R., Bakal, D.A., Dunn, B.E. Psychosomatic medicine. (1990) [Pubmed]
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