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Gene Review

NPT1  -  nicotinate phosphoribosyltransferase

Saccharomyces cerevisiae S288c

Synonyms: NAPRTase, Nicotinate phosphoribosyltransferase, YOR209C
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High impact information on NPT1


Biological context of NPT1

  • Both NPT1 and SIR2 provide resistance against heat shock, demonstrating that these genes act in a more general manner to promote cell survival [2].
  • The overall NAPRTase reaction involves phosphorylation of a low-affinity form of the enzyme by ATP, followed by generation of a high-affinity form of the enzyme, which then binds substrates and produces NAMN [4].

Associations of NPT1 with chemical compounds

  • We now show that mutation of a highly conserved histidine residue in Npt1p results in a silencing defect, indicating that Npt1p enzymatic activity is required for silencing [5].
  • In Saccharomyces cerevisiae the nicotinic acid moiety of NAD+ can be synthesized from tryptophan using the kynurenine pathway or incorporated directly using nicotinate phosphoribosyl transferase (NPT1) [6].

Regulatory relationships of NPT1

  • Although SIR2-dependent processes are enhanced by additional NPT1, steady-state NAD(+) levels and NAD(+)/NADH ratios remain unaltered [2].

Analytical, diagnostic and therapeutic context of NPT1


  1. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Lin, S.J., Defossez, P.A., Guarente, L. Science (2000) [Pubmed]
  2. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. Anderson, R.M., Bitterman, K.J., Wood, J.G., Medvedik, O., Cohen, H., Lin, S.S., Manchester, J.K., Gordon, J.I., Sinclair, D.A. J. Biol. Chem. (2002) [Pubmed]
  3. Kinetic analysis of nicotinate phosphoribosyltransferase from yeast using high pressure liquid chromatography. Hanna, L.S., Hess, S.L., Sloan, D.L. J. Biol. Chem. (1983) [Pubmed]
  4. Conversion of a cosubstrate to an inhibitor: phosphorylation mutants of nicotinic acid phosphoribosyltransferase. Rajavel, M., Lalo, D., Gross, J.W., Grubmeyer, C. Biochemistry (1998) [Pubmed]
  5. Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Sandmeier, J.J., Celic, I., Boeke, J.D., Smith, J.S. Genetics (2002) [Pubmed]
  6. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. Panozzo, C., Nawara, M., Suski, C., Kucharczyka, R., Skoneczny, M., Bécam, A.M., Rytka, J., Herbert, C.J. FEBS Lett. (2002) [Pubmed]
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