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Gene Review

ATR1  -  Atr1p

Saccharomyces cerevisiae S288c

Synonyms: Aminotriazole resistance protein, SNQ1, YM8339.03, YML116W
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Disease relevance of ATR1

  • In order to analyze whether membrane transporters of the facilitator or the ABC type (SNQ1 and SNQ2) have an influence on Sn2+ toxicity in yeast we used the respective mutants and compared their responses to the wild type (WT) [1].

High impact information on ATR1

  • Here, we isolated a new gene, designated ATR1, which when present in multiple copies per cell allowed gcn4 mutant strains to grow in the presence of aminotriazole [2].
  • The deduced amino acid sequence suggests that ATR1 protein is very hydrophobic with many membrane-spanning regions, has several potential glycosylation sites, and may contain an ATP-binding site [2].
  • Overexpression of ATR1, another YAP1-regulated gene previously implicated in conferring resistance to a number of cytotoxic drugs, was also incapable of making cells resistant to Cer [3].
  • Two S. cerevisiae ORFs of known multidrug-resistance function (ATR1, SGE1) fall into cluster II [4].
  • The isolated gene exhibited 48.9% identity with the S. cerevisiae ATR1 gene conferring resistance to aminotriazole and 4-nitroquinoline- N-oxide and encoded a protein of 553 amino acids [5].

Biological context of ATR1


Associations of ATR1 with chemical compounds


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