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Chemical Compound Review

4-NITROQUINOLINE-N-OXIDE     4-nitro-1-oxido-quinoline

Synonyms: Nitrochin, CCRIS 458, N8141_ALDRICH, QUI043, CHEMBL127655, ...
 
 
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Disease relevance of 4-NITROQUINOLINE-N-OXIDE

 

High impact information on 4-NITROQUINOLINE-N-OXIDE

 

Chemical compound and disease context of 4-NITROQUINOLINE-N-OXIDE

 

Biological context of 4-NITROQUINOLINE-N-OXIDE

 

Anatomical context of 4-NITROQUINOLINE-N-OXIDE

  • There were no significant differences in the number of Ia+ EDC between the infiltrating and the non-invasive overlying epithelium of the lingual carcinomas and the non-invasive lingual epithelium treated with either 4NQO or 4NQO + C.parvum.(ABSTRACT TRUNCATED AT 400 WORDS)[4]
  • This study examined the characteristics of premalignant oral epithelial cell lines derived from non-invasive palatal and lingual mucosa of rats painted with the carcinogen 4-nitroquinoline N-oxide (4NQO) in vivo [18].
  • Stationary cultures of human fibroblasts were exposed to various doses of carcinogens (UV-light at 254 nm, N-acetoxy-acetyl-aminofluorene, ethyl-methane sulfonate, N-methylnitro-nitrosoguanidine, mitomycin C and 4-nitroquinoline-N-oxide) at different time-intervals before preparing crude cellular extracts and assaying for ligase activity [19].
  • BALB/c-3T3 cells displayed a dose-dependent transformation response to a variety of carcinogens (polycyclic hydrocarbons, methylating agents, ethylating agents, aflatoxin B1 [AFB1], and 4-nitroquinoline-N-oxide [4-NQO]) [20].
  • It is suggested that de novo formation of free oral sebaceous glands is caused by a metaplastic process due to local irritants among which the carcinogen 4NQO seems particularly powerful [21].
 

Associations of 4-NITROQUINOLINE-N-OXIDE with other chemical compounds

 

Gene context of 4-NITROQUINOLINE-N-OXIDE

 

Analytical, diagnostic and therapeutic context of 4-NITROQUINOLINE-N-OXIDE

References

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