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Gene Review

PGM2  -  phosphoglucomutase PGM2

Saccharomyces cerevisiae S288c

Synonyms: D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase, GA-5, GAL5, Glucose phosphomutase 2, PGM 2, ...
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High impact information on PGM2

  • In striking contrast to other galactose-inducible genes, the GAL5 gene exhibited an unusually high GAL4-independent basal level of expression [1].
  • The Saccharomyces cerevisiae GAL5 (PGM2) gene was isolated and shown to encode the major isozyme of phosphoglucomutase [1].
  • Northern (RNA) blot hybridization revealed that the GAL5 transcript level increased three- to fourfold in response to galactose and was severely repressed in response to glucose [1].
  • The gal3gal5 and gal3pgi1 double mutants were not inducible, whereas both the gal5 and pgi1 single mutants were inducible [2].
  • This conclusion was supported by measurements of sugar phosphates, which showed that there were increased concentrations of glucose-6-phosphate, galactose-6-phosphate, and fructose-6-phosphate in the strain construct overexpressing PGM2 [3].

Biological context of PGM2


Associations of PGM2 with chemical compounds

  • This indicated that PGM2 is a target for overexpression in terms of increasing the flux through the Leloir pathway, and through overexpression of PGM2 the galactose uptake rate could be increased by 70% compared to that of the reference strain [3].

Other interactions of PGM2

  • We did, however, find that PGM2, encoding the major isoenzyme of phosphoglucomutase, was slightly up-regulated in the two recombinant strains with higher galactose uptake rates [3].


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