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Gene Review

Pgm1  -  phosphoglucomutase 1

Rattus norvegicus

Synonyms: Glucose phosphomutase 1, PGM 1, Phosphoglucomutase-1
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Disease relevance of Pgm1

  • Diazinon, an organophosphorous compound, produced hyperglycemia and reduced the glycogen content of the brain 2 h after its administration to rats (40 mg/kg, i.p.). The activities of the glycogenolytic enzymes, glycogen phosphorylase and phosphoglucomutase, were significantly increased, while that of glucose-6-phosphatase was not altered [1].

Psychiatry related information on Pgm1

  • The extent of the increase was greater in alcohol-fed rats than in pair-fed controls, suggesting enhanced enzyme activities toward ADP-ribosylation of PGM after chronic alcohol consumption [2].

High impact information on Pgm1


Biological context of Pgm1


Anatomical context of Pgm1


Associations of Pgm1 with chemical compounds


Other interactions of Pgm1


Analytical, diagnostic and therapeutic context of Pgm1

  • During the four weeks period of immobilization a 20% decrease occurred in PGM activity, to which no limiting role in glycolysis is attributed, while PyK which has a regulatory function, showed a 35% decrease in EDL; at the same time in the soleus the activity of these enzymes did not change [19].
  • The activity of glycogen phosphorylase, glucose 6-phosphatase and phosphoglucomutase showed higher levels in the liver of low protein high cyanide group compared to the control group [20].
  • The effect of immobilization by plaster cast was studied on the activities of phosphoglucomutase (PGM), pyruvate kinase ( PyK ) and cAMP-dependent protein kinase in fast (extensor digitorum longus [EDL]), and slow (soleus) muscles of rats [19].


  1. Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. Husain, K., Ansari, R.A. Can. J. Physiol. Pharmacol. (1988) [Pubmed]
  2. Long-term alcohol intake enhances ADP-ribosylation of the multifunctional enzyme, phosphoglucomutase, in rat liver. Nomura, F., Noda, M., Miyake, M., Nakai, T. Hepatology (1996) [Pubmed]
  3. L-lactate dehydrogenase A4- and A3B isoforms are bona fide peroxisomal enzymes in rat liver. Evidence for involvement in intraperoxisomal NADH reoxidation. Baumgart, E., Fahimi, H.D., Stich, A., Völkl, A. J. Biol. Chem. (1996) [Pubmed]
  4. Glucose 6-phosphate regulates Ca2+ steady state in endoplasmic reticulum of islets. A possible link in glucose-induced insulin secretion. Wolf, B.A., Colca, J.R., Comens, P.G., Turk, J., McDaniel, M.L. J. Biol. Chem. (1986) [Pubmed]
  5. Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. Hanson, R.L., Ho, R.S., Wiseberg, J.J., Simpson, R., Younathan, E.S., Blair, J.B. J. Biol. Chem. (1984) [Pubmed]
  6. The addition of glucose-1-phosphate to the cytoplasmic glycoprotein phosphoglucomutase is modulated by intracellular calcium in PC12 cells and rat cortical synaptosomes. Veyna, N.A., Jay, J.C., Srisomsap, C., Bounelis, P., Marchase, R.B. J. Neurochem. (1994) [Pubmed]
  7. Long-term alcohol effects on hepatic phosphoglucomutase activities in relation to posttranslational modification of the protein. Nomura, F., Miyake, M., Noda, M., Itoga, S., Nakai, T. Alcohol. Clin. Exp. Res. (1998) [Pubmed]
  8. Relationship between oxidative stress and hepatic phosphoglucomutase activity in rats. Kanazawa, K., Ashida, H. International journal of tissue reactions. (1991) [Pubmed]
  9. Kinetics and dose dependence of glutathione, glutathione-S-transferase and phosphoglucomutase in liver and kidney of nickel treated partially hepatectomized rats. Dwivedi, P.P., Behari, J.R., Misra, M., Srivastava, R.C. Industrial health. (1985) [Pubmed]
  10. Glucose-stimulated protein phosphorylation in the pancreatic islet. Colca, J.R., Kotagal, N., Lacy, P.E., Brooks, C.L., Norling, L., Landt, M., McDaniel, M.L. Biochem. J. (1984) [Pubmed]
  11. Isolation and immunohistochemical localization of a chondroitin sulfate proteoglycan from adult rat brain. Normand, G., Kuchler, S., Meyer, A., Vincendon, G., Zanetta, J.P. J. Neurochem. (1988) [Pubmed]
  12. Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus. Kershaw, E.E., Chua, S.C., Williams, J.A., Murphy, E.M., Leibel, R.L. Genomics (1995) [Pubmed]
  13. Renal hypertrophy in experimental diabetes. Effect of diabetes on the pathways of glucose metabolism: differential response in adult and immature rats. Sochor, M., Kunjara, S., Greenbaum, A.L., McLean, P. Biochem. J. (1986) [Pubmed]
  14. Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Agius, L., Peak, M. Biochem. J. (1993) [Pubmed]
  15. Effects of lithium on the activities of phosphofructokinase and phosphoglucomutase and on glucose-1,6-diphosphate levels in rat muscles, brain and liver. Nordenberg, J., Kaplansky, M., Beery, E., Klein, S., Beitner, R. Biochem. Pharmacol. (1982) [Pubmed]
  16. The effect of epinephrine and dibutyryl cyclic AMP on glucose 1,6-bisphosphate levels and the activities of hexokinase, phosphofructokinase and phosphoglucomutase in the isolated rat diaphragm. Beitner, R., Haberman, S., Nordenberg, J. Mol. Cell. Endocrinol. (1978) [Pubmed]
  17. An inverse relation between mitochondrial hexokinase content and phosphoglucomutase activity of rat tissues. Wilson, J.E., Felgner, P.L. Mol. Cell. Biochem. (1977) [Pubmed]
  18. Decreased phosphofructokinase activity in skeletal muscle of diabetic rats. Bauer, B.A., Younathan, E.S. Clinical physiology and biochemistry. (1984) [Pubmed]
  19. Effect of immobilization on some glycolytic enzymes of skeletal muscle. Vereb, G., Bot, G., Szücs, K., Kovács, E., Erdödi, F., Kalapos, I., Szöör, A., Rapcsák, M., Szilágyi, T. Acta physiologica Hungarica. (1984) [Pubmed]
  20. Hyperglycemic effect of low protein cassava diet. Sreeja, V.G., Leelamma, S. Indian J. Exp. Biol. (1998) [Pubmed]
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