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Gene Review

RHO2  -  Rho family GTPase RHO2

Saccharomyces cerevisiae S288c

Synonyms: GTP-binding protein RHO2, N2237, YNL090W
 
 
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High impact information on RHO2

  • Inactivation of these genes showed that RHO1 is required for cell viability, while RHO2 is not an essential gene [1].
  • ROM2 and RHO2 were identified in a screen for high-copy number suppressors of cik1 delta, a mutant defective in microtubule-based processes in Saccharomyces cerevisiae [2].
  • Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae [3].
  • Since none of the suppressors, except Rho2p, can correct the phenotype of the pfy1-111/rho2Delta strain, we propose a model in which the suppressors act through the Rho2p signaling pathway to repolarize cortical actin patches [3].
  • Yeast phosphatidylinositol 4-phosphate 5-kinases Mss4 and Its3 are involved in resistance against disturbance of sphingolipid biosynthesis and maintenance of cell integrity through the synthesis of PtdIns(4,5)P2 and downstream signalling through the Rom2/Rho2 and Rgf1/Rho pathways [4].
 

Anatomical context of RHO2

 

Other interactions of RHO2

  • These genes were called rho1+ and rho2+ [6].
  • Interestingly, while the MKT1 and END3 coding polymorphisms contribute to phenotype, it is the RHO2 3'UTR polymorphisms that are phenotypically relevant [7].

References

  1. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Madaule, P., Axel, R., Myers, A.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Manning, B.D., Padmanabha, R., Snyder, M. Mol. Biol. Cell (1997) [Pubmed]
  3. Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae. Marcoux, N., Cloutier, S., Zakrzewska, E., Charest, P.M., Bourbonnais, Y., Pallotta, D. Genetics (2000) [Pubmed]
  4. Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools. Santarius, M., Lee, C.H., Anderson, R.A. Biochem. J. (2006) [Pubmed]
  5. Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe. Santos, B., Gutiérrez, J., Calonge, T.M., Pérez, P. Eukaryotic Cell (2003) [Pubmed]
  6. Isolation and sequencing of two cDNA clones encoding Rho proteins from the fission yeast Schizosaccharomyces pombe. Nakano, K., Mabuchi, I. Gene (1995) [Pubmed]
  7. Complex genetic interactions in a quantitative trait locus. Sinha, H., Nicholson, B.P., Steinmetz, L.M., McCusker, J.H. PLoS Genet. (2006) [Pubmed]
 
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