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Gene Review

BNI4  -  Bni4p

Saccharomyces cerevisiae S288c

Synonyms: N1146, Protein BNI4, YNL233W
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High impact information on BNI4

  • This localization is dependent on the septins, Bni4p, and Chs3p [1].
  • Overexpression of Bni4p also causes delocalization of chitin deposition and produces a cellular morphology similar to that of septin mutants [1].
  • Immunolocalization experiments show that Bni4p localizes to a ring at the mother-bud neck that lies predominantly on the mother-cell side (corresponding to the predominant site of chitin deposition) [1].
  • We show herein that Bni4 is also a limiting determinant for the targeting of the type 1 serine/threonine phosphatase (Glc7) to the bud neck [2].
  • A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence [2].

Biological context of BNI4


  1. A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. DeMarini, D.J., Adams, A.E., Fares, H., De Virgilio, C., Valle, G., Chuang, J.S., Pringle, J.R. J. Cell Biol. (1997) [Pubmed]
  2. A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Kozubowski, L., Panek, H., Rosenthal, A., Bloecher, A., DeMarini, D.J., Tatchell, K. Mol. Biol. Cell (2003) [Pubmed]
  3. Candida albicans mutants in the BNI4 gene have reduced cell-wall chitin and alterations in morphogenesis. Rowbottom, L., Munro, C.A., Gow, N.A. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Saccharomyces cerevisiae Bni4p directs the formation of the chitin ring and also participates in the correct assembly of the septum structure. Sanz, M., Castrejón, F., Durán, A., Roncero, C. Microbiology (Reading, Engl.) (2004) [Pubmed]
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