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Gene Review

PEX17  -  Pex17p

Saccharomyces cerevisiae S288c

Synonyms: N1319, PAS9, Peroxin-17, Peroxisomal membrane protein PEX17, YNL214W
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High impact information on PEX17

  • From these and other studies we conclude that Pex17p, in addition to Pex13p and Pex14p, is the third identified component of the peroxisomal translocation machinery [1].
  • Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery [1].
  • Particulate structures containing the peroxisomal integral membrane proteins Pex3p and Pex11p are evident in pex17 mutant cells, indicating the existence of peroxisomal remnants ("ghosts") [1].
  • The Saccharomyces cerevisiae pex17-1 mutant was isolated from a screen to identify mutants defective in peroxisome biogenesis. pex17-1 and pex17 null mutants fail to import matrix proteins into peroxisomes via both PTS1- and PTS2-dependent pathways [1].
  • This finding suggests that pex17 null mutant cells are not impaired in peroxisomal membrane biogenesis [1].

Anatomical context of PEX17

  • However, localization studies demonstrate that Pex17p is a peripheral membrane protein located at the surface of peroxisomes [1].
  • PpPex17p behaves as an integral PMP with a cytosolic carboxyl-terminal domain. pex17Delta mutants accumulate peroxisomal matrix proteins and certain integral PMPs in the cytosol, suggesting a critical role for Pex17p in their localization [2].

Associations of PEX17 with chemical compounds

  • Synthesis of Pex17p is low in cells grown in glucose-containing medium and increases after the cells are shifted to oleic acid-containing medium [3].
  • Clones were sought which restored the ability of pas9 cells to grow on oleate as a sole carbon source, as oleate metabolism requires peroxisomal beta-oxidation and therefore functional peroxisomes [4].

Physical interactions of PEX17


Other interactions of PEX17


  1. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. Huhse, B., Rehling, P., Albertini, M., Blank, L., Meller, K., Kunau, W.H. J. Cell Biol. (1998) [Pubmed]
  2. Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris. Snyder, W.B., Koller, A., Choy, A.J., Johnson, M.A., Cregg, J.M., Rangell, L., Keller, G.A., Subramani, S. Mol. Biol. Cell (1999) [Pubmed]
  3. The peroxin Pex17p of the yeast Yarrowia lipolytica is associated peripherally with the peroxisomal membrane and is required for the import of a subset of matrix proteins. Smith, J.J., Szilard, R.K., Marelli, M., Rachubinski, R.A. Mol. Cell. Biol. (1997) [Pubmed]
  4. Isolation of a cDNA encoding an Arabidopsis galactokinase by functional expression in yeast. Kaplan, C.P., Tugal, H.B., Baker, A. Plant Mol. Biol. (1997) [Pubmed]
  5. Peroxisomal membrane protein import does not require Pex17p. Harper, C.C., South, S.T., McCaffery, J.M., Gould, S.J. J. Biol. Chem. (2002) [Pubmed]
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